JKE-1716 - ≥98% , CAS No.2421118-05-8

CAS: 2421118-05-8 Cat. No.: J647661 Fórmula: C₂₀H₂₀Cl₂N₄O₄ Peso molecular: 451.30 PubChem CID: 145865953

CALIDAD & PUREZA ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition

In Vitro

JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability. JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: LOX-IMVI cells Concentration: 0~100 nΜ Incubation Time: 72 hours Result: Inhibited cell viability.

Form:Solid

IC50& Target:GPX4, ,Ferroptosis

Especificaciones

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ACTIVATOR

Pureza

≥98%

Nombres e identificadores

Sonrisas canónicas

C1CN(CCN1C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)C(=O)CC(=NO)[N+](=O)[O-]

IUPAC Name

(3Z)-1-[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]-3-hydroxyimino-3-nitropropan-1-one

InChIKey

HZFRTZXJNACSIE-NKFKGCMQSA-N

INCHI

1S/C20H20Cl2N4O4/c21-16-5-1-14(2-6-16)20(15-3-7-17(22)8-4-15)25-11-9-24(10-12-25)19(27)13-18(23-28)26(29)30/h1-8,20,28H,9-13H2/b23-18-

PubChem CID

145865953

Peso molecular

451.30