Kazusamycin B - ≥95% , CAS No.107140-30-7

CAS: 107140-30-7 Cat. No.: K329568 Molecular Weight: 542.7 PubChem CID: 6436293

GRADE & PURITY ≥95%

Synonyms

2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-8-oxo- | (2E,10E,12E,16Z,18E)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Kazusamycin B is a minor component of the leptomycin complex produced from the fermentation of the broth of a|Streptomyces sp.|. The compound is a hydroxylated analogue of Leptomycin A , a nuclear export inhibitor, and highly lipophillic.|In vitro|antitumor activity of Kazusamycin B on tumors L1210, P388/S, B16, HeLa S3, L5178Y-ML or L929 was ascertained to have an IC|50|of 1.8, 2.0, 0.7, 1.8, 10.0 and l.0 ng/ml when cultured in the presence of Kazusamycin B for 72 hours. The compound has also displayed broad antitumor activity in mice with effectiveness being more dependent on dosing regimen than dosing concentration both|in vivo|and|in vitro|. Kazusamycin B also possesses antibacterial and antifungal activity.

Specifications

Synonyms

2, 10, 12, 16, 18-Nonadecapentaenoic acid, 19-(3, 6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-9-(hydroxymethyl)-3, 5, 7, 11, 15, 17-hexamethyl-8-oxo- | (2E, 10E, 12E, 16Z, 18E)-6-hydroxy-9-(hydroxymethyl)-3, 5, 7, 11, 15, 17-hexamethyl-19-(3-methyl-6-oxo-3, 6-dihydro-2

Specifications & Purity

≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(CO)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C
• IUPAC Name: (2E,10E,12E,16Z,18E)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• InChIKey: OOQHBJFDAPXZJM-BBHORLQHSA-N
• INCHI: 1S/C32H46O7/c1-20(15-22(3)11-13-28-24(5)12-14-30(36)39-28)9-8-10-21(2)17-27(19-33)32(38)26(7)31(37)25(6)16-23(4)18-29(34)35/h8,10-15,17-18,20,24-28,31,33,37H,9,16,19H2,1-7H3,(H,34,35)/b10-8+,13-11+,21-17+,22-15-,23-18+
• Isomeric SMILES: CC1C=CC(=O)OC1/C=C/C(=C\C(C)C/C=C/C(=C/C(CO)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C
• RTECS: OA0551000
• PubChem CID: 6436293
• Molecular Weight: 542.7

Chemical and Physical Properties

• Solubility: Soluble in ethanol, methanol, DMSO, and DMF.