4-Hydrazinyl-1-methylpiperidine Dihydrochloride: FAQs

4-Hydrazinyl-1-methylpiperidine dihydrochloride is a bifunctional heterocyclic building block featuring both a piperidine nitrogen and a hydrazino group, making it a versatile intermediate for medicinal chemistry and the synthesis of nitrogen-rich heterocyclic compounds.

Product Name

4-Hydrazinyl-1-methylpiperidine dihydrochloride

SKU

H727697

Functional Groups

Hydrazino (–NHNH2) and tertiary amine (N-methyl piperidine)

Physical Form

Solid salt (dihydrochloride)

Primary Use

Synthetic building block for heterocyclic and medicinal chemistry

Storage Recommendation

Store in a cool, dry place; protect from moisture and light

What Is 4-Hydrazinyl-1-methylpiperidine Dihydrochloride?

4-Hydrazinyl-1-methylpiperidine dihydrochloride (SKU: H727697) is a piperidine-based hydrazine derivative supplied as its dihydrochloride salt to improve stability and handling. The molecule carries two key nitrogen-containing functionalities: a hydrazino group (–NHNH₂) at the 4-position of the piperidine ring, and an N-methyl group on the ring nitrogen. This dual-functionality allows the compound to participate in a broad range of condensation, cyclization, and coupling reactions commonly used in drug discovery and fine chemical synthesis.

The dihydrochloride salt form renders the compound easier to weigh, store, and handle compared with the free base, which is typically more hygroscopic and sensitive to oxidation.

Handling, Safety, and Storage

As with all hydrazine-containing compounds, appropriate laboratory precautions should be taken when handling 4-Hydrazinyl-1-methylpiperidine dihydrochloride. Hydrazine derivatives are generally considered potential irritants to skin, eyes, and the respiratory tract. Personnel should wear appropriate personal protective equipment (PPE), including nitrile gloves, safety glasses, and a lab coat, and work in a well-ventilated fume hood.

For storage, keep the compound in a tightly sealed container in a cool, dry location, away from strong oxidizing agents, light, and moisture. Under recommended conditions, the dihydrochloride salt form offers improved shelf stability relative to the free base. Refer to the Safety Data Sheet (SDS) provided by Aladdin Scientific for complete hazard and first-aid information before use.

Research and Synthetic Applications

4-Hydrazinyl-1-methylpiperidine dihydrochloride serves as a valuable building block in medicinal chemistry programs, particularly in the design and synthesis of biologically active nitrogen-containing heterocycles. The free hydrazino group can react with carbonyl compounds (aldehydes and ketones) to form hydrazones, or with 1,3-dicarbonyl equivalents and other electrophilic partners to yield pyrazoles, triazoles, and related ring systems.

The N-methylpiperidine moiety introduces conformational rigidity and favorable physicochemical properties (such as improved aqueous solubility and modulated lipophilicity) that are desirable in drug candidates. Researchers in target-focused library synthesis, fragment-based drug discovery, and lead optimization commonly employ such bifunctional piperidine-hydrazine scaffolds to explore structure–activity relationships (SAR).

Ordering and Product Specifications

4-Hydrazinyl-1-methylpiperidine dihydrochloride is available from Aladdin Scientific under SKU H727697. Researchers requiring detailed specification data, including purity grade, molecular weight, melting point, and batch-specific Certificate of Analysis (CoA), should consult the product page on the Aladdin Scientific website or contact technical support directly.

For bulk quantities, custom packaging, or specific purity requirements beyond standard catalog grades, please reach out to the Aladdin Scientific sales team to discuss custom synthesis or large-volume procurement options. Orders can be placed online, by phone, or through an authorized distributor.

Frequently asked questions

What is the molecular structure of 4-Hydrazinyl-1-methylpiperidine dihydrochloride?

The compound consists of a six-membered piperidine ring bearing an N-methyl substituent on the ring nitrogen and a hydrazino (–NHNH2) group at the 4-position. It is supplied as the dihydrochloride salt, meaning two equivalents of hydrochloric acid are associated with the free-base form to give a stable, crystalline solid.

How should I convert the dihydrochloride salt to the free base for reactions that require neutral conditions?

To liberate the free base, the dihydrochloride salt can typically be treated with an aqueous base such as sodium hydroxide or potassium carbonate, followed by extraction into a suitable organic solvent (e.g., ethyl acetate or dichloromethane). The free base should then be dried over anhydrous magnesium or sodium sulfate and used promptly, as hydrazine free bases are generally more sensitive to oxidation and moisture than their salt forms.

What types of chemical reactions can 4-Hydrazinyl-1-methylpiperidine dihydrochloride be used in?

The hydrazino group is nucleophilic and can condense with aldehydes and ketones to form hydrazones, or react with beta-ketoesters, 1,3-diketones, and related electrophiles to form heterocyclic rings such as pyrazoles and triazoles. These reactions are widely used in the preparation of pharmacologically relevant scaffolds in medicinal chemistry and combinatorial library synthesis.

What are the recommended storage conditions for H727697?

Store 4-Hydrazinyl-1-methylpiperidine dihydrochloride in a tightly sealed container in a cool, dry place, protected from light and moisture, and away from incompatible materials such as strong oxidizing agents. Always consult the current SDS from Aladdin Scientific for the most up-to-date handling and storage guidance.

Is a Certificate of Analysis (CoA) available for H727697?

Yes, batch-specific Certificates of Analysis are available for H727697. You can request the CoA for a specific lot number through the Aladdin Scientific website product page or by contacting Aladdin Scientific customer service with your lot number.

References

1. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. General reference for hydrazone and heterocycle formation reactions.
2. Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry. Oxford University Press. General reference for piperidine and hydrazine chemistry.
3. Aladdin Scientific product page for H727697: 4-Hydrazinyl-1-methylpiperidine dihydrochloride.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.