KIN101 - 10mM in DMSO , CAS No.610753-87-2

CAS: 610753-87-2 Cat. No.: K656659 Fórmula: C₁₆H₁₁BrO₅S Peso molecular: 395.22 PubChem CID: 1998840

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

KIN101 is a potent RNA viral inhibitor with IC 50 s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses

In Vitro

KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC 50 of 0.2 μM. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells. KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5. KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MRC5 cells Concentration: 10 μM Incubation Time: 24 hours Result: Caused a significant decrease in the NP protein abundance. RT-PCRCell Line: Huh7 cells Concentration: 10 μM Incubation Time: 18 hours Result: Showed a >1 log decrease in HCV RNA levels.

IC50& Target:IC50: 2 μM (influenza virus) and >5 μM (DNV)

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

KIN101 is a potent RNA viral inhibitor with IC 50 s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activit

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: CS(=O)(=O)OC1=CC2=C(C=C1)C(=O)C(=CO2)C3=CC=C(C=C3)Br
• PubChem CID: 1998840
• Peso molecular: 395.22

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 610753-87-2, the molecular formula is C16H11BrO5S, and the molecular weight is 395.22 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.