Levonorgestrel - Moligand™, 10mM in DMSO , Progesterone receptor agonist, CAS No.797-63-7, Progesterone receptor agonist

CAS: 797-63-7 Cat. No.: L409272 Fórmula: C₂₁H₂₈O₂ Peso molecular: 312.45 Número EC: 212-349-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

D-Norgestrel | 13-ethyl-17-hydroxy-, (17α)-18,19-Dinorpregn-4-en-20-yn-3-one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.
In vitro

Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects

In vivo

Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

D-Norgestrel | 13-ethyl-17-hydroxy-, (17α)-18,19-Dinorpregn-4-en-20-yn-3-one

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Levonorgestrel (D-Norgestrel) is a female hormone that prevents ovulation.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Progesterone receptor agonist

Nombres e identificadores

• Isómeros SMILES: CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34
• WGK Alemania: 3
• RTECS: JF8259000
• Peso molecular: 312.45
• Reaxy-Rn: 24733492
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24733492&ln=

Objetivos asociados (humanos)

PGR Tclin Progesterone receptor (0 Activities)

Discover Target: PGR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 30 mg/mL (197.17 mM); Ethanol: 30 mg/mL (197.17 mM); Water: Insoluble
• Rotación específica [α]: [α]D：-34~-31° (C=1,CHCl3)
• Punto de fusión (°C): 236℃

Referencias

1. Xu Jiaqi, Li Qianyu, Li Wenrui, Wu Di, Wu Yongning, Li Guoliang.  (2025)  Efficient adsorption and detection of steroid hormones in foods through the combination of novel magnetic TAPB-COF materials with click isotope probes.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:39820674] [10.1007/s00216-024-05727-6]

2. Fang Zhao, Zhao Yang, Yifan Xiao, Ganghua Han, Kim R. Hardie, Mark Bartlam, Yingying Wang.  (2025)  Enantioselective interactions of silver nanoparticles and chiral antibiotics in driving resistance evolution in activated sludge.  WATER RESEARCH,      [PMID:41038122] [10.1016/j.watres.2025.124656]

3. Mingyao Yuan, Yefan Wu, Zhilin Li, Zhenxing Zeng, Hong Peng, Hong Xiao, Xiaohui Lu, Yanzong Zhang, Shihuai Deng, Guochun Lv, Xiaojing Wang.  (2025)  Comparably effective elimination of several antibiotics from water: Elastic complementarity between radical and non-radical active species in catalytic systems.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2025.122586]

4. Qiuye Jin, Qiong Duan, Dingyu Ji, Jie Chang, Zhaomin Tang.  (2023)  Reaction mechanism, degradation pathway and toxicity assessment of NH4+ enhanced potassium ferrate removal of levofloxacin.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,      [PMID:] [10.1016/j.psep.2023.10.037]

5. Guangli Li, Xuan Wan, Yonghui Xia, Du Tuo, Xiaoman Qi, Tianyu Wang, Mohammad Mehmandoust, Nevin Erk, Quanguo He, Qing Li.  (2023)  Lamellar α-Zirconium Phosphate Nanoparticles Supported on N-Doped Graphene Nanosheets as Electrocatalysts for the Detection of Levofloxacin.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.3c03162]

6. Tingting Li, Guoqiang Guo, Haoming Xing, Siyuan Tang, Houwen Hu, Linfan Wang, Xiaoqing Qian, Da Chen.  (2023)  Construction of fluorescent sensor array and three-dimensional microfluidic paper based analytical device for specific identification and visual determination of antibiotics in food.  FOOD CHEMISTRY,      [PMID:37499515] [10.1016/j.foodchem.2023.136947]

7. Donghui Wang, Yu-e Shi, Zhen Zhang, Song Shen, Zhenguang Wang.  (2022)  Modulating Emission of Organic Emitters from Fluorescence to Red Afterglow through Boric Acid-Assisted Energy Transfer.  Journal of Physical Chemistry C,      [PMID:] [10.1021/acs.jpcc.2c07138]

8. Anhua Jiang, Xinwen Huang, Geshan Zhang, Wanquan Yang.  (2022)  A Study of the Degradation of LEV by Transparent PVA/NCD-TiO2 Nanocomposite Films with Enhanced Visible-Light Photocatalytic Activity.  Catalysts,  12  (11): (1336).  [PMID:] [10.3390/catal12111336]

9. Qinyue Wu, Yan Zhang, He Liu, Hongbo Liu, Jia Tao, Min-Hua Cui, Zhiyong Zheng, Donghui Wen, Xinmin Zhan.  (2022)  FexN produced in pharmaceutical sludge biochar by endogenous Fe and exogenous N doping to enhance peroxymonosulfate activation for levofloxacin degradation.  WATER RESEARCH,      [PMID:36099758] [10.1016/j.watres.2022.119022]

10. Xiang-Yu Zheng, Hai-Chen Zhang, Yu-Dan Lv, Feng-Yan Jin, Xiu-Juan Wu, Jie Zhu, Yang Ruan.  (2022)  Levetiracetam alleviates cognitive decline in Alzheimer's disease animal model by ameliorating the dysfunction of the neuronal network..  Frontiers in Aging Neuroscience,      [PMID:36092803] [10.3389/fnagi.2022.888784]

11. Yichen Zhang, Shugui Hua, Xiaoqin Sun, Zhuoyue Liu, Yuan Dang, Liang Zhang, Yuanzhen Zhou.  (2021)  A novel electrochemical cathode based on sea urchin-like NiO/Co3O4 composite inducing efficient Fenton-like process for levofloxacin degradation.  APPLIED CATALYSIS A-GENERAL,      [PMID:] [10.1016/j.apcata.2021.118403]

12. Yafeng Jin, Guangri Xu, Xiaobo Li, Jingjing Ma, Li Yang, Yuanchao Li, Huan Zhang, Zhen Zhang, Donghao Yao, Donghao Li.  (2020)  Fast cathodic reduction electrodeposition of a binder-free cobalt-doped Ni-MOF film for directly sensing of levofloxacin.  JOURNAL OF ALLOYS AND COMPOUNDS,      [PMID:] [10.1016/j.jallcom.2020.156823]

13. Huikai Shao, Haibo Zhou, Tingting Zhang, Xianglong Zhao, Zhengjin Jiang, Qiqin Wang.  (2018)  Preparation of molecularly imprinted hybrid monoliths for the selective detection of fluoroquinolones in infant formula powders.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:30587346] [10.1016/j.chroma.2018.12.038]

14. Liu Chaoqiao, Xie Dong, Liu Peng, Xie Shilei, Wang Shoushan, Cheng Faliang, Zhang Min, Wang Lishi.  (2018)  Voltammetric determination of levofloxacin using silver nanoparticles deposited on a thin nickel oxide porous film.  MICROCHIMICA ACTA,  186  (1): (1-10).  [PMID:30554349] [10.1007/s00604-018-3146-2]

15. Sun Yao, Duan Runbin, Li Yuzhen, Lu Xinyu, Gao Jiangqi, Zhu Bingzi.  (2025)  Adsorption kinetics of three fluoroquinolone carboxylic acids on red clay soil in five types of aqueous solutions.  AQUA-Water Infrastructure Ecosystems and Society,  74  (2): (159-174).  [PMID:] [10.2166/aqua.2025.238]

16. Gege Cheng, Fajian Zeng, Xiuyu Liu, Qiuni Yang, Shizhen Wei, Qin Huang.  (2025)  Mussel-inspired adhesive and tough hydrogel for drug release based on lignin-containing cellulose nanofiber.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40010454] [10.1016/j.ijbiomac.2025.141458]