LR-90 - Moligand™,10mM in DMSO , CAS No.245075-84-7

CAS: 245075-84-7 Cat. No.: L654803 Fórmula: C₃₅H₃₄Cl₂N₄O₈ Peso molecular: 709.57 PubChem CID: 10212249

CALIDAD & PUREZA Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes LR-90 is also used in the research of diabetic animal model .

In Vitro

LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours. LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours. LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: THP-1 cells Concentration: 0, 25, 50, 100, and 200 μM Incubation Time: 24 hours Result: Showed no cytotoxicity to THP-1 cells. RT-PCRCell Line: THP-1 cells Concentration: 0, 25, 50, 100, and 200 μM Incubation Time: One hour before S100b addition for 4 hours Result: Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b.

In Vivo

LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats. LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male ZDF rats (13 to 40 weeks)Dosage: 50 mg/L Administration: P.O. for 27 weeks Result: Significantly reduced plasma triacylglycerol and cholesterol by ∼55% and ∼30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight.

IC50& Target:AGE

Especificaciones

Especificaciones y pureza

Moligand™,10mM in DMSO

Mecanismos bioquímicos y fisiológicos

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES

CC(C)(C(=O)O)OC1=CC=C(C=C1)NC(=O)NC2=C(C=C(C=C2)CC3=CC(=C(C=C3)NC(=O)NC4=CC=C(C=C4)OC(C)(C)C(=O)O)Cl)Cl

PubChem CID

10212249

Peso molecular

709.57

Preguntas frecuentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 245075-84-7, the molecular formula is C35H34Cl2N4O8, and the molecular weight is 709.57 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.