LUF5771 - ≥98% , CAS No.1141802-49-4

CAS: 1141802-49-4 Cat. No.: L650188 Molecular Weight: 357.4 PubChem CID: 44572264

GRADE & PURITY ≥98%

Synonyms

6XGG437C7W | HY-139303 | 5-Phenyl-(1,1'-biphenyl)-3-yl N-cyclopentylcarbamate | (1,1':3',1''-Terphenyl)-5'-yl N-cyclopentylcarbamate | LUF5771 | LUF-5771 | UNII-6XGG437C7W | MS-25609 | Cyclopentyl-carbamic acid [1,1'',3'',1'''']terphenyl-5''-yl ester | 11

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

LUF5771 is a potent allosteric recombinant luteinizing hormone ( recLH ) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy

In Vitro

LUF5771 (1 µM or 10 µM) allosteric inhibition is concentration-dependent. LUF5771 significantly increases radioligand dissociation. LUF5771 probably binds to the seven transmembrane domain like Org 43553 does. LUF5771 (10 µM) alone is able to partially activate the LH receptor by 31±4%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:recLH and Org 43553

Specifications

Synonyms

6XGG437C7W | HY-139303 | 5-Phenyl-(1, 1'-biphenyl)-3-yl N-cyclopentylcarbamate | (1, 1':3', 1''-Terphenyl)-5'-yl N-cyclopentylcarbamate | LUF5771 | LUF-5771 | UNII-6XGG437C7W | MS-25609 | Cyclopentyl-carbamic acid [1, 1'', 3'', 1'''']terphenyl-5''-yl ester | 11

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

LUF5771 is a potent allosteric recombinant luteinizing hormone ( recLH ) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C1CCC(C1)NC(=O)OC2=CC(=CC(=C2)C3=CC=CC=C3)C4=CC=CC=C4
• IUPAC Name: (3,5-diphenylphenyl) N-cyclopentylcarbamate
• InChIKey: YNYOWRRXJIPCGX-UHFFFAOYSA-N
• INCHI: 1S/C24H23NO2/c26-24(25-22-13-7-8-14-22)27-23-16-20(18-9-3-1-4-10-18)15-21(17-23)19-11-5-2-6-12-19/h1-6,9-12,15-17,22H,7-8,13-14H2,(H,25,26)
• Isomeric SMILES: C1CCC(C1)NC(=O)OC2=CC(=CC(=C2)C3=CC=CC=C3)C4=CC=CC=C4
• Alternate CAS: 1141802-49-4
• PubChem CID: 44572264
• MeSH Entry Terms: cPrCA-terphenyl ester;cyclopentylcarbamic acid (1,1',2',1'')terphenyl-5'-yl ester;LUF 5771;LUF-5771;LUF5771
• Molecular Weight: 357.4

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Terphenyls

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Terphenyls
• Intermediate Tree Nodes: Not available
• Direct Parent: M-terphenyls
• Alternative Parents: Biphenyls and derivatives Phenoxy compounds Carbamate esters Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Meta-terphenyl - Biphenyl - Phenoxy compound - Carbamic acid ester - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as m-terphenyls. These are terphenyls with a structure containing the 1,3-diphenylbenzene skeleton.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

LHCGR Tclin Luteinizing hormone/Choriogonadotropin receptor (373 Activities)

Discover Target: LHCGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (279.77 mM; Need ultrasonic)
• Molecular Weight: 357.400 g/mol
• XLogP3: 6.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 357.173 Da
• Monoisotopic Mass: 357.173 Da
• Topological Polar Surface Area: 38.300 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 435.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1