M4K2234 - ≥98% , CAS No.2421141-51-5

CAS: 2421141-51-5 Cat. No.: M651872 Molecular Weight: 462.56

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC 50 s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer

In Vitro

M4K2234 (0-5 μM) shows inhibitory effects against WT and DIPG-linked mutant forms of ALK2 with IC 50 s of 5, 3, 6 and 6 nM for WT, G328V, R206H and R258G, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

1.19 Pharmacokinetic Properties of M4K2234 in Mice . Mice PO 3 mg/kg C max (ng/mL) 1650 AUC inf (ng·h/mL) 4630 t 1/2 (h) 2.61 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 5 nM (ALK2 WT), 3 nM (ALK2 G328V), 6 nM (ALK2 R206H), 6 nM (ALK2 R258G), 2144 nM (ALK5)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC 50 s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Molecular Weight: 462.56

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (216.19 mM; Need ultrasonic)