Mangiferina - Moligand™, ≥95% , CAS No.4773-96-0

CAS: 4773-96-0 Cat. No.: M196329 Fórmula: C₁₉H₁₈O₁₁ Peso molecular: 422.34 Número EC: 624-757-7

GRADE & PURITY Moligand™, ≥95%

Synonyms

1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one | DTXCID70119754 | UNII-1M84LD0UMD | AS-15337 | 9H-Xanthen-9-one, 2-b-D-glucopyranosyl-1,3,6,7-tetrahydroxy- | NSC 248870 | Chinoinin | MANGIFERIN [USP-RS]

Storage

Conservar a 2-8°C

Shipped In

Hielo húmedo

Descripción general

Descripción del producto：

La mangiferina (MGF) es un polifenol bioactivo natural aislado predominantemente del árbol Mangifera indica (Mango). Tiene una estructura de xantona glucósido. La maniferina también puede encontrarse en otras plantas angiospermas y hierbas.

Aplicación del producto：

La mangiferina se ha utilizado
como patrón de referencia para la caracterización de la mangiferina de Mangifera indica mediante ultrasonidos con partición trifásica (UTPP)
para estudiar sus efectos en la promoción del fenotipo adiposo marrón de las células madre mesenquimales (MSC) murinas C3H10T1/2 y su papel en la biogénesis mitocondrial y la homeostasis
como patrón de referencia para la determinación cuantitativa de compuestos marcadores en el cultivo de brotes de Swertia paniculata mediante cromatografía en capa fina de alto rendimiento.

Specifications

Sinónimos

1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one | DTXCID70119754 | UNII-1M84LD0UMD | AS-15337 | 9H-Xanthen-9-one, 2-b-D-glucopyranosyl-1,3,6,7-tetrahydroxy- | NSC 248870 | Chinoinin | MANGIFERIN [USP-RS]

Especificaciones y pureza

Moligand™, ≥95%

Mecanismos bioquímicos y fisiológicos

La mangiferina posee diversas propiedades farmacológicas, entre ellas actividades antioxidantes, antidiabéticas, antibacterianas, cardioprotectoras, neuroprotectoras e inmunomoduladoras. También ha mostrado propiedades antidiabéticas, antihiperlipidémicas

Condiciones de almacenamiento de almacenamiento

Conservar a 2-8°C

Enviado en

Hielo húmedo

Grado

Moligand™

Pureza

≥95%

Nombres e identificadores

Pubchem Sid

504763370

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504763370

Sonrisas canónicas

C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O

IUPAC Name

1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one

InChIKey

AEDDIBAIWPIIBD-ZJKJAXBQSA-N

INCHI

1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1

Isómeros SMILES

C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O

Peso molecular

422.34

Reaxy-Rn

1359328

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1359328&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzopyrans
      • Subclass 1-benzopyrans
        • Level5 Dibenzopyrans
          • Level6 Xanthenes
            • Level7 Xanthones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans - Xanthenes
• Direct Parent: Xanthones
• Alternative Parents: Phenolic glycosides Hexoses C-glycosyl compounds Chromones Pyranones and derivatives 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Oxanes Vinylogous acids Heteroaromatic compounds Secondary alcohols Polyols Oxacyclic compounds Dialkyl ethers Organic oxides Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenolic glycoside - Xanthone - Hexose monosaccharide - C-glycosyl compound - Chromone - Glycosyl compound - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Benzenoid - Pyran - Oxane - Monosaccharide - Heteroaromatic compound - Vinylogous acid - Secondary alcohol - Oxacycle - Polyol - Dialkyl ether - Ether - Hydrocarbon derivative - Organic oxygen compound - Organic oxide - Organooxygen compound - Primary alcohol - Alcohol - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.
• External Descriptors: xanthenes

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

AKR1B1 Tclin Aldose reductase (1404 Activities)

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MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

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U2OS (164939 Activities)

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NUDT1 Tchem 7,8-dihydro-8-oxoguanine triphosphatase (280 Activities)

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Objetivos asociados (no humanos)

NA Neuraminidase (1107 Activities)

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Gusb Beta-glucuronidase (17 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Plasmodium falciparum (966862 Activities)

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Rattus norvegicus (775804 Activities)

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Human alphaherpesvirus 1 (11089 Activities)

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3T3-L1 (3664 Activities)

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BHK-21 (725 Activities)

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Vero (26788 Activities)

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BV-2 (3710 Activities)

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Genome polyprotein (620 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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nanH Sialidase (337 Activities)

Discover Target: nanH

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Glyceraldehyde-3-phosphate dehydrogenase, glycosomal (75 Activities)

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Danio rerio (3092 Activities)

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Plasma (328 Activities)

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SARS-CoV-2 (38078 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Heat Sensitive
• Punto de fusión (°C): 270 °C
• Peso molecular: 422.300 g/mol
• XLogP3: -0.400
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 2
• Exact Mass: 422.085 Da
• Monoisotopic Mass: 422.085 Da
• Topological Polar Surface Area: 197.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 646.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1