Maprotiline HCl - 10mM in DMSO , Norepinephrine transporter inhibitor, CAS No.10347-81-6, Norepinephrine transporter inhibitor

CAS: 10347-81-6 Cat. No.: M408267 Fórmula: C₂₀H₂₃N·HCl Peso molecular: 313.86 Número EC: 233-758-8

GRADE & PURITY 10mM in DMSO

Synonyms

N-​methyl-​9,​10-​ethanoanthracene-​9(10H)​-​propanamine,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Maprotiline HCl Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
In vitro

Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum.

In vivo

Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training.
Cell Data

cell lines：HUVEC, SH-SY5Y, IGR-N91 and IGR-NB8 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

N-​methyl-​9,​10-​ethanoanthracene-​9(10H)​-​propanamine,hydrochloride (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Mecanismo de acción

Norepinephrine transporter inhibitor

Nombres e identificadores

• Isómeros SMILES: CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl
• WGK Alemania: 3
• RTECS: KJ4555000
• Peso molecular: 313.86
• Reaxy-Rn: 5463242
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5463242&ln=

Propiedades químicas y físicas

• Punto de fusión (°C): 242 °C

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 10347-81-6, the molecular formula is C20H24ClN, and the molecular weight is 313.86 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.