MK-0557 - 10mM in DMSO , CAS No.328232-95-7

CAS: 328232-95-7 Cat. No.: M654757 Molecular Weight: 406.41 PubChem CID: 11491176

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a K i of 1.6 nM.

In Vitro

Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target. MK-0557 has a K i =1.3 nM at the human NPY5R, with similar affinities at rhesus, mouse, and rat NPY5R. MK-0557 has no significant binding to the human NPY1R, NPY2R, NPY4R, or mouse NPY6R at concentrations of 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice. When lean mice on regular chow are switched to a medium high-fat diet (4.2 kcal/g) and treated with MK-0557 at 30 mg/kg PO QD, MK-0557 causes a 40% reduction in\nbody-weight gain at day 35. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NPY Y 5 receptor

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a K i of 1.6 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Names and Identifiers

• Isomeric SMILES: C1CC2(CCC1C(=O)NC3=NN(C=C3)C4=CC=CC=C4F)C5=C(C=CN=C5)C(=O)O2
• Alternate CAS: 328232-95-7,935765-76-7
• PubChem CID: 11491176
• MeSH Entry Terms: MK-0557;MK0557;spiro(cyclohexane-1,3'(1'H)-furo(3,4-C)pyridine)-4-carboxamide, N-(1-(2-fluorophenyl)-1h-pyrazol-3-yl)-1'-oxo-, trans-;trans-N-(1-(2-fluorophenyl)-3-pyrazolyl)-3-oxospiro(6-azaisobenzofuran-1(3H),1'-cyclohexane)-4'-carboxamide
• Molecular Weight: 406.41