ML161 (Parmodulin 2) - 10mM in DMSO , CAS No.423735-93-7

CAS: 423735-93-7 Cat. No.: M408640 Molecular Weight: 361.23 EC Number: 803-969-5

GRADE & PURITY 10mM in DMSO

Synonyms

Benzamide, 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

ML161 (Parmodulin 2) ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.
In vitro

ML-161 is an allosteric inhibitor of PAR1. ML-161 displays dose-dependent inhibition of thrombin-induced platelet activation, as measured by P-selectin expression. ML-161 displays selective inhibition of SFLLRN and thrombin-induced platelet aggregation, both of which operate via PAR1, and has no effect on AYPGKF, thromboxane, or ADP-induced platelet aggregation, which are all agonists at alternative platelet GPCRs.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Benzamide, 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

ML161 (Parmodulin 2) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CCCC(=O)NC1=CC(=CC=C1)NC(=O)C2=CC=CC=C2Br
• WGK Germany: 3
• Molecular Weight: 361.23
• Reaxy-Rn: 22413221
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22413221&ln=