≥99% para flujos de trabajo cromatográficos y analíticos sensibles que requieren una interferencia mínima de la línea base.
Protected from light,Store at -80°C Envío Dry ice packs + Cold packs. Consulte el COA específico del lote para conocer las especificaciones exactas.
SDS, COA, ficha técnica y hoja de especificaciones disponibles para descargar. COA específico del lote accesible mediante búsqueda por número de lote.
Citado en 0 publicaciones revisadas por pares sobre cromatografía, síntesis orgánica y reacciones de acoplamiento cruzado.
MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity ( IC 50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia
In Vitro
MM-401 maintains high binding affinity to WDR5 with a K i value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC 50 value of 0.9 nM. MM-401 is able to specifically inhibit MLL1 activity (IC 50 value of 0.32µM) by blocking MLL1-WDR5 interaction and thus the complex assembly. MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells. MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion. MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Specifically induced apoptosis of MLL-AF9 cells. Cell Cycle AnalysisCell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner. RT-PCRCell Line: MLL-AF9 cells Concentration: 20 μM Incubation Time: 48 h Result: Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10.
Form:Solid
IC50& Target:Ki: < 1 nM (WDR5),IC50: 0.9 nM (WDR5-MLL1 interaction), 0.32 µM (MLL1)
Documento completo sobre peligros, manipulación, almacenamiento y cumplimiento normativo.
<<<<<<< HEAD Descargar SDS → ======= Descargar SDS → >>>>>>> release248-p3Datos de calidad específicos del lote. Introduzca su número de lote para obtener el COA exacto.
Buscar COA →Resumen de referencia rápida de las especificaciones y aplicaciones del producto.
Ver ficha técnica →Atributos de calidad completos y criterios de aceptación para esta calidad.
Ver hoja de especificaciones →| Solubilidad | DMSO : 100 mg/mL (142.70 mM; ultrasonic and warming and heat to 60°C) |
|---|
