Morinidazole - 10mM in DMSO , CAS No.92478-27-8

CAS: 92478-27-8 Cat. No.: M656785 Fórmula: C₁₁H₁₈N₄O₄ Peso molecular: 270.29 PubChem CID: 11644726

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N + -glucuronidation and sulfation. Morinidazole can be used for bacterial infections research including appendicitis and pelvic inflammatory disease (PID) caused by anaerobic bacteria

In Vitro

Morinidazole can be metabolized to N + -glucuronide of S-morinidazole [M8-1] and N + -glucuronide of R-morinidazole [M8-2] via N + -glucuronidation, and sulfate conjugate of morinidazole [M7] via sulfation. M7 is a substrate for organic anion transporter 1 (OAT1) and OAT3 (K m =28.6 and 54.0 μM, respectively), M8-1 and M8-2 are the substrates for OAT3. Morinidazole shows activity against Trichomonas vaginalis and Entamoeba histolytica in vitro, with MIC values of 2 μg/mL and 3 μg/mL, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Morinidazole (20 mg/kg or 25 mg/kg; p.o.; single dose) inhibits Trichomonas vaginalis and Entamoeba histolytica in vivo in rats with EC 50 s of 20 mg/kg and 25 mg/kg, respectively. Morinidazole (50 mg/kg; i.v.; 0.25, 0.75, 1.5 h) shows a different concentration in tissues after intravenous injection, with a higher concentration in liver, kidney, plasma than lung, heart, and spleen in mice. Pharmacokinetic parameters of Morinidazole in control and 5/6 nephrectomized (Nx) ratsGroup C max (μg/mL) T max (h) T 1/2 (h) AUC 0-t (μg·h/mL) AUC 0-∞ (μg·h/mL) CL (mL/h/kg) V ss (mL/kg) MRT (h) Control rats 48.2 0.08 1.16 87.2 87.3 582 805 1.39 5/6 Nx rats 53.2 0.08 1.32 91.2 91.3 552 891 1.62 Intravenous injection; 50 mg/kg Morinidazole; Blood samples were collected from retro-orbital venous plexus before the dose (0 hours), at 5, 15, and 30 minutes, and at 1, 2, 4, 6, 8, and 12 hours after the dose. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Renal failure model in SD rats (180-220 g)Dosage: 50 mg/kg Administration: Intravenous injection; sacrificed rats at 0.25, 0.75, and 1.50 hours after dose administration Result: Increased plasma exposures slightly compared with control.

IC50& Target:organic anion transporter

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Morinidazole is an orally active and 5-nitroimidazole antimicrobial agent that undergoes extensive metabolism in humans via N + -glucuronidation and sulfation. Morinidazole can be used for bacterial infections research including appendicitis and pelvic in

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CC1=NC=C(N1CC(CN2CCOCC2)O)[N+](=O)[O-]
• CAS alternativo: 92478-27-8
• PubChem CID: 11644726
• Términos de entrada MeSH: morinidazole
• Peso molecular: 270.29

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 92478-27-8, the molecular formula is C11H18N4O4, and the molecular weight is 270.29 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.