MRT68921 HCl - ≥98% , CAS No.1190379-70-4(freebase)

CAS: 1190379-70-4(freebase) Cat. No.: M413884 Fórmula: C₂₅H₃₄N₆O·xHCl Peso molecular: 434.6（freebase）

GRADE & PURITY ≥98%

Synonyms

N-​[3-​[[5-​cyclopropyl-​2-​[(1,​2,​3,​4-​tetrahydro-​2-​methyl-​6-​isoquinolinyl)​amino]​-​4-​pyrimidinyl]​amino]​propyl]​-Cyclobutanecarboxamide hydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Information

MRT68921 HCl MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

Targets

ULK2 (Cell-free assay); ULK1 (Cell-free assay) 1.1 nM; 2.9 nM

In vitro

MRT68921 specifically disrupts autophagosome maturation and thus blocks autophagic flux through ULK1 inhibition.

Cell Research(from reference)

Cell lines：MEFs and 293T cells 

Concentrations：1 μM 

Incubation Time：1 h 

Specifications

Sinónimos

N-​[3-​[[5-​cyclopropyl-​2-​[(1,​2,​3,​4-​tetrahydro-​2-​methyl-​6-​isoquinolinyl)​amino]​-​4-​pyrimidinyl]​amino]​propyl]​-Cyclobutanecarboxamide hydrochloride

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.Mrt68921 hydrochloride has cytotoxicity and kills cancer cells by acting on oxidative stress signals. It is an effective tumor therapeutic drug. M

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Propiedades del producto

• ALogP: 4.644
• hba_count: 3
• Recuento HBD: 3
• Enlace rotable: 9

Nombres e identificadores

• Sonrisas canónicas: CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C4CC4)C(=N3)NCCCNC(=O)C5CCC5
• CAS alternativo: 2080306-21-2
• Peso molecular: 434.6（freebase）
• Reaxy-Rn: 19608518
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19608518&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 10 mg/mL warmed with 50ºC Water: bath Water: Insoluble; Ethanol: Insoluble
• DMSO (mg/ml) Solubilidad máxima: 10
• DMSO (mM) Solubilidad máxima: 23.010723
• Agua (mg/ml) Solubilidad máxima: ＜1

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1190379-70-4(freebase), the molecular formula is C25H34N6O·xHCl, and the molecular weight is 434.6（freebase） g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.