MS140 - ≥96% , CAS No.2229974-83-6

CAS: 2229974-83-6 Cat. No.: M414502 Fórmula: C₃₉H₄₀N₁₀O₇ Peso molecular: 760.8

GRADE & PURITY ≥96%

Synonyms

1H-​Isoindole-​1,​3(2H)​-​dione,4-​[[2-​[4-​[6-​[(6-​acetyl-​8-​cyclopentyl-​7,​8-​dihydro-​5-​methyl-​7-​oxopyrido[2,​3-​d]​pyrimidin-​2-​yl)​amino]​-​3-​pyridinyl]​-​1-​piperazinyl]​-​2-​oxoethyl]​amino]​-​2-​(2,​6-​dioxo-​3-​piperidinyl)​-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Information

MS140 MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).

Targets

CDK4 ; CDK6

In vitro

MS140 potently and selectively both inhibits and degrades CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4–CRBN–E3 ubiquitin complex.

In vivo

Treatment of mice with MS140 promoted degradation of CDK4/6 kinases and suppression of RB–E2F output in JeKo-1 (MCL) and Colo25 (colorectal carcinoma) xenografts in vivo.

Cell Research(from reference)

Cell lines：Colo205 cells 

Concentrations：0.3\u2009μM 

Incubation Time：5\u2009h 

Specifications

Sinónimos

1H-​Isoindole-​1,​3(2H)​-​dione,4-​[[2-​[4-​[6-​[(6-​acetyl-​8-​cyclopentyl-​7,​8-​dihydro-​5-​methyl-​7-​oxopyrido[2,​3-​d]​pyrimidin-​2-​yl)​amino]​-​3-​pyridinyl]​-​1-​piperazinyl]​-​2-​oxoethyl]​amino]​-​2-​(2,​6-​dioxo-​3-​piperidinyl)​-

Especificaciones y pureza

≥96%

Mecanismos bioquímicos y fisiológicos

MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥96%

Nombres e identificadores

• Pubchem Sid: 504773173
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773173
• Sonrisas canónicas: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C
• IUPAC Name: 4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]-2-oxoethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• InChIKey: IWFNIKIERKCKFZ-UHFFFAOYSA-N
• INCHI: 1S/C39H40N10O7/c1-21-26-19-42-39(45-34(26)48(23-6-3-4-7-23)37(55)32(21)22(2)50)43-29-12-10-24(18-41-29)46-14-16-47(17-15-46)31(52)20-40-27-9-5-8-25-33(27)38(56)49(36(25)54)28-11-13-30(51)44-35(28)53/h5,8-10,12,18-19,23,28,40H,3-4,6-7,11,13-17,20H2,1-2H3,(H,44,51,53)(H,41,42,43,45)
• Peso molecular: 760.8
• Reaxy-Rn: 33062994
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33062994&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 10 mg/mL (13.14 mM); Water: Insoluble; Ethanol: Insoluble
• Peso molecular: 760.800 g/mol
• XLogP3: 2.200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 9
• Exact Mass: 760.308 Da
• Monoisotopic Mass: 760.308 Da
• Topological Polar Surface Area: 207.000 Ų
• Heavy Atom Count: 56
• Formal Charge: 0
• Complexity: 1660.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥96% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2229974-83-6, the molecular formula is C39H40N10O7, and the molecular weight is 760.8 g/mol. InChIKey IWFNIKIERKCKFZ-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.