MS432 - ≥98% , CAS No.2672512-44-4

CAS: 2672512-44-4 Cat. No.: M649435 Fórmula: C₅₀H₆₅F₃IN₇O₆S Peso molecular: 1076.06

GRADE & PURITY ≥98%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Application

PROTAC

Descripción general

MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau -recruiting PROTAC degrader for MEK1 and MEK2 . MS432 displays good plasma exposure in mice, exhibiting DC 50 values of 31 nM and 17 nM for MEK1 , MEK2 in HT29 cells respectively

In Vitro

MS432 (compound 23) is potent in reducing MEK1/2 protein levels in COLO 205 cells (DC 50 (MEK1) = 18 ± 7 nM, DC 50 (MEK2) = 11 ± 2 nM) and UACC257 cells (DC 50 (MEK1) = 56 ± 25 nM, DC 50 (MEK2) = 27 ± 19 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: (HT-29, SK-MEL-28, COLO 205 and UACC 257 cell lines. Concentration: 0-1 μM. Incubation Time: 72 hours. Result: Effectively inhibited proliferation of these CRC and melanoma cells in a concentration-dependent manner, with GI 50 values ranging from 30 to 200 nM.

In Vivo

MS432 (compound 23) displays good plasma exposure, which is approximately 3 to 20-fold higher than the GI 50 values of compound 23 in the tested cancer cell lines . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Swiss Albino mice . Dosage: 50 mg/kg (Pharmacokinetic Analysis). Administration: IP Result: Displays good plasma exposure with the maximum plasma concentration of 1,400 nM detected at 0.5 hour post dosing and plasma concentration of 710 nM at 8 hours post dosing.

Form:Solid

IC50& Target:MEK1 31 nM (DC 50 , in HT29 cells) MEK2 17 nM (DC 50 , in HT29 cells) MEK1 31 nM (DC 50 , in SK-MEL-28 cells) MEK2 9.3 nM (DC 50 , in SK-MEL-28 cells)

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau -recruiting PROTAC degrader for MEK1 and MEK2 . MS432 displays good plasma exposure in mice, exhibiting DC 50 values of 31 nM and 17 nM for MEK1 , MEK2 in HT29 cells respecti

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C,Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 1076.06

Propiedades químicas y físicas

• Solubilidad: DMSO : 260 mg/mL (241.62 mM; Need ultrasonic)

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2672512-44-4, the molecular formula is C50H65F3IN7O6S, and the molecular weight is 1076.06 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.