≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
MYF-01-37 MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein.
Targets
TEAD
In vitro
MYF-01-37 is developed as a covalent binder to TEAD, targeting Cys380 when incubated with the TEAD2 protein (C359 in TEAD1). Pretreating cells with MYF-01-37 leads to loss of direct TEAD pull-down by biotin-MYF-01-037 from whole-cell lysate, confirming MYF-01-037 binding to TEAD in cells.
Cell Research(from reference)
Cell lines：PC9 cells
Concentrations：10 μM, 1 μM
Incubation Time：6 h
| Pubchem Sid | 504773627 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773627 |
| Canonical Smiles | CC1(CCN(C1)C(=O)C=C)NC2=CC=CC(=C2)C(F)(F)F |
| IUPAC Name | 1-[3-methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one |
| InChIKey | MTBDEVWWJBIUOK-UHFFFAOYSA-N |
| INCHI | 1S/C15H17F3N2O/c1-3-13(21)20-8-7-14(2,10-20)19-12-6-4-5-11(9-12)15(16,17)18/h3-6,9,19H,1,7-8,10H2,2H3 |
| Molecular Weight | 298.3 |
| Reaxy-Rn | 36048179 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=36048179&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2629026 | Certificate of Analysis | Jun 05, 2026 | M414290 |
| F2214780 | Certificate of Analysis | Mar 04, 2025 | M414290 |
| F2214781 | Certificate of Analysis | Mar 04, 2025 | M414290 |
| F2215015 | Certificate of Analysis | Mar 04, 2025 | M414290 |
| Solubility | Solubility (25°C) In vitro DMSO: 60 mg/mL (201.13 mM); Ethanol: 60 mg/mL (201.13 mM); Water: Insoluble; |
|---|---|
| Molecular Weight | 298.300 g/mol |
| XLogP3 | 3.300 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 298.129 Da |
| Monoisotopic Mass | 298.129 Da |
| Topological Polar Surface Area | 32.299 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 410.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
