N6-Ethyladenosine - ≥99% , CAS No.14357-08-5

CAS: 14357-08-5 Cat. No.: N651026 Fórmula: C₁₂H₁₇N₅O₄ Peso molecular: 295.29 PubChem CID: 15160100

GRADE & PURITY ≥99%

Synonyms

NSC-516603 | n6-ethyladenosine | Adenosine, N-ethyl- | (2R,3R,4S,5R)-2-(6-(Ethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | HY-111809 | MS-24224 | Z1980898342 | SCHEMBL6758546 | 5D56H6D7ZZ | AKOS030575552 | N-Ethyladenosine | 6-Ethyl

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with K i s of 4.9 and 4.7 nM for hA 1 AR and hA 3 AR, respectively

In Vitro

N6-Ethyladenosine (Compound 28) exhibits more selectivity at hA 1 AR and hA 3 AR over hA 2 AR (K i , 8900±770 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Ki: 4.9 nM (hA 1 AR), 4.7 nM (hA 3 AR)

Specifications

Sinónimos

NSC-516603 | n6-ethyladenosine | Adenosine, N-ethyl- | (2R,3R,4S,5R)-2-(6-(Ethylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | HY-111809 | MS-24224 | Z1980898342 | SCHEMBL6758546 | 5D56H6D7ZZ | AKOS030575552 | N-Ethyladenosine | 6-Ethyl

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with K i s of 4.9 and 4.7 nM for hA 1 AR and hA 3 AR, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

AGONIST

Pureza

≥99%

Nombres e identificadores

Sonrisas canónicas

CCNC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O

IUPAC Name

(2R,3R,4S,5R)-2-[6-(ethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

InChIKey

SHXVYOLWYFZWKE-WOUKDFQISA-N

INCHI

1S/C12H17N5O4/c1-2-13-10-7-11(15-4-14-10)17(5-16-7)12-9(20)8(19)6(3-18)21-12/h4-6,8-9,12,18-20H,2-3H2,1H3,(H,13,14,15)/t6-,8-,9-,12-/m1/s1

Isómeros SMILES

CCNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

CAS alternativo

14357-08-5

PubChem CID

15160100

Peso molecular

295.29

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Clase Purine nucleosides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Clase: Purine nucleosides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Purine nucleosides
• Alternative Parents: Glycosylamines 6-alkylaminopurines Pentoses Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Oxolanes Heteroaromatic compounds Secondary alcohols Oxacyclic compounds Azacyclic compounds Primary alcohols Hydrocarbon derivatives Amines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Purine nucleoside - Glycosyl compound - N-glycosyl compound - 6-alkylaminopurine - 6-aminopurine - Pentose monosaccharide - Purine - Imidazopyrimidine - Aminopyrimidine - Imidolactam - Pyrimidine - N-substituted imidazole - Monosaccharide - Heteroaromatic compound - Oxolane - Azole - Imidazole - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Azacycle - Hydrocarbon derivative - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Alcohol - Amine - Primary alcohol - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : ≥ 83.33 mg/mL (282.20 mM)
• Peso molecular: 295.290 g/mol
• XLogP3: 0.000
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 295.128 Da
• Monoisotopic Mass: 295.128 Da
• Topological Polar Surface Area: 126.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 363.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 14357-08-5, the molecular formula is C12H17N5O4, and the molecular weight is 295.29 g/mol. InChIKey SHXVYOLWYFZWKE-WOUKDFQISA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.