10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 ( ALDH1A1 ) inhibitors with an IC 50 of 7 nM.
In Vitro
NCT-506 inhibits ALDH1A1, hALDH1A3, hALDH2 with IC 50 s of 0.007±0.001, 16.4±3.99, and 21.5 μM, respectively. NCT-506 (100, 10, 1, 0.1 μM, 6 days) decreases significantly cell viability with an EC 50 of 45.6 μM in OV-90 cells. NCT-506 inhibits MIA PaCa-2, OV-90, and HT-29 cells with IC 50 s of 0.077±0.040, 0.161±0.038, and 0.048±0.022 μM in aldefluor cell-based assays, respectively. NCT-506 is treated in combined with Paclitaxel, IC 50 s of 1202, 924, 870, 411, 102, and 31.8 nM with concentrations of NCT-506 at 0 (DMSO), 1, 3, 10, 20, 30 μM in SKOV-3-TR cells, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: OV-90 and SKOV-3-TR cells Concentration: 100, 10, 1, 0.1 μM Incubation Time: 6 days for OV-90 cells; 4 days for SKOV-3-TR cells Result: Decreased significantly cell viability with an EC 50 of 45.6 μM in OV-90 cells. Decreased cell viability in combined treatments (Paclitaxel concentration of 100 nM) with an EC 50 of 11.2 μM in SKOV-3-TR cells.
| Isómeros SMILES | CS(=O)(=O)N1CCN(CC1)C(=O)C2=CN=C3C=CC(=CC3=C2C4=CC=C(C=C4)C5(CC5)C#N)F |
|---|---|
| PubChem CID | 137628670 |
| Peso molecular | 478.54 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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