Neoantimycin - ≥95% , CAS No.22862-63-1

CAS: 22862-63-1 Cat. No.: N329566 Fórmula: C₃₆H₄₆N₂O₁₂ Peso molecular: 698.76

CALIDAD & PUREZA ≥95%

Synonyms

1,4,8,11-Tetraoxacyclopentadecane, neoantimycin deriv. | 3-(Formylamino)-2-hydroxy-N-[(3S,6S,7R,10S,14R,15R)-14-hydroxy-7,13,13-trimethyl-3-(1-methylethyl)-10-[(1S)-1-methylpropyl]-2,5,9,12-tetraoxo-15-(phenylmethyl)-1,4,8,11-tetraoxacyclopentadec-6-yl]be

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Neoantimycin is a macrocyclic antibiotic isolated from|Streptomyces|bacteria. The mechanism of action of Neoantimycin is undescribed in the literature. A closely related compound described as an oxidized-type neoantimycin, prunustatin A, is demonstrated to downregulate grp78 transcription and suppress the expression of the GRP 78 molecular chaperone. This suppression affects the role of GRP 78 in promoting protein folding at the endoplasmic reticulum (ER), and suppresses the pro-resistance enhancement of ER stress response by chemotherapy-resistant tumors. The close structural kinship between prunustatin A and Neoantimycin suggests a similar mechanism of action for Neoantimycin toxicity.

Especificaciones

Sinónimos

1,4,8,11-Tetraoxacyclopentadecane, neoantimycin deriv. | 3-(Formylamino)-2-hydroxy-N-[(3S,6S,7R,10S,14R,15R)-14-hydroxy-7,13,13-trimethyl-3-(1-methylethyl)-10-[(1S)-1-methylpropyl]-2,5,9,12-tetraoxo-15-(phenylmethyl)-1,4,8,11-tetraoxacyclopentadec-6-yl]be

Especificaciones y pureza

≥95%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥95%

Nombres e identificadores

Pubchem Sid

528771978

Sonrisas canónicas

CCC(C)C1C(=O)OC(C(C(=O)OC(C(=O)OC(C(C(C(=O)O1)(C)C)O)CC2=CC=CC=C2)C(C)C)NC(=O)C3=C(C(=CC=C3)NC=O)O)C

IUPAC Name

N-(15-benzyl-10-butan-2-yl-14-hydroxy-7,13,13-trimethyl-2,5,9,12-tetraoxo-3-propan-2-yl-1,4,8,11-tetraoxacyclopentadec-6-yl)-3-formamido-2-hydroxybenzamide

InChIKey

JIJATTFJYJZEBT-UHFFFAOYSA-N

INCHI

1S/C36H46N2O12/c1-8-20(4)29-34(45)47-21(5)26(38-31(42)23-15-12-16-24(27(23)40)37-18-39)32(43)49-28(19(2)3)33(44)48-25(17-22-13-10-9-11-14-22)30(41)36(6,7)35(46)50-29/h9-16,18-21,25-26,28-30,40-41H,8,17H2,1-7H3,(H,37,39)(H,38,42)

Isómeros SMILES

CCC(C)C1C(=O)OC(C(C(=O)OC(C(=O)OC(C(C(C(=O)O1)(C)C)O)CC2=CC=CC=C2)C(C)C)NC(=O)C3=C(C(=CC=C3)NC=O)O)C

Peso molecular

698.76

Reaxy-Rn

3116939

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3116939&ln=

Propiedades químicas y físicas

• Solubilidad: Soluble in ethanol, methanol, DMF, and DMSO.
• Índice de refracción: n20D1.58 (Predicted)
• Punto de ebullición (°C): 930.35° C at 760 mmHg (Predicted)