NKY 80 - Moligand™, ≥98% , Inhibitor of adenylyl cyclase 5;Inhibitor of adenylyl cyclase 6, CAS No.299442-43-6, Inhibitor of adenylyl cyclase 5;Inhibitor of adenylyl cyclase 6

CAS: 299442-43-6 Cat. No.: N276064 Fórmula: C₁₂H₁₁N₃O₂ Peso molecular: 229.24 Número EC: 663-524-4

GRADE & PURITY Moligand™, ≥98%

Synonyms

2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one | MFCD02026323 | AKOS000301518 | AKOS016042252 | CCG-16635 | Adenylyl Cyclase Type V Inhibitor, NKY80 | 2-amino-7-(furan-2-yl)-5,6,7,8-tetrahydroquinazolin-5-one | NKY 80 | 2-amino-7-(furan-2-yl)-7,8-dih

Storage

Protegido de la luz,Almacenar a -20°C,Cargado con argón,Desecado

Shipped In

Hielera + almohadillas de hielo

Descripción general

Almacenar a -20°C. Almacenar en condiciones de desecación. El producto puede almacenarse hasta 12 meses.

Una quinazolinona permeable a las células que contiene un compuesto no nucleósido que actúa como inhibidor potente y selectivo de la isoforma tipo V de la adenilil ciclasa (AC) (IC50 = 8,3 µM, 132 µM y 1,7 mM para los tipos V, III y II, respectivamente) en presencia de Gsα GTPγS-Forskolin. Muestra una selectividad ~210 veces mayor para el tipo V que para la isoforma de tipo II. La inhibición no es competitiva con respecto al ATP y la forskolina. Regula la actividad catalítica de la AC en tejidos cardíacos y pulmonares.

Compuesto no nucleósido permeable a las células que actúa como inhibidor potente y selectivo de la adenilil ciclasa (AC) tipo V (IC50 = 8,3 µM, 132 µM y 1,7 mM para los tipos V, III y II, respectivamente) en presencia de G5α GTPγS-Forskolina. Muestra una selectividad ~210 veces mayor para el tipo V que para la isoforma de tipo II. La inhibición no es competitiva con respecto al ATP y la forskolina. Se ha descrito que regula la actividad catalítica de la AC en tejidos cardíacos y pulmonares.

Aplicación：

Una quinazolinona permeable a las células que contiene un compuesto no nucleósido que actúa como inhibidor potente y selectivo de la isoforma tipo V de la adenilil ciclasa (AC)

Specifications

Sinónimos

2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one | MFCD02026323 | AKOS000301518 | AKOS016042252 | CCG-16635 | Adenylyl Cyclase Type V Inhibitor, NKY80 | 2-amino-7-(furan-2-yl)-5,6,7,8-tetrahydroquinazolin-5-one | NKY 80 | 2-amino-7-(furan-2-yl)-7,8-dih

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Inhibidor selectivo de la adenilil ciclasa 5 (los valores de IC 50 son 8, 132 y 1700 μM para AC5, AC3 y AC2 respectivamente). Permeable a las células. No competitivo con ATP y forskolina. Regula la actividad catalítica de la AC en tejidos cardíacos y pulm

Condiciones de almacenamiento de almacenamiento

Protegido de la luz,Almacenar a -20°C,Cargado con argón,Desecado

Enviado en

Hielera + almohadillas de hielo

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of adenylyl cyclase 5;Inhibitor of adenylyl cyclase 6

Nota

Siempre que sea posible, prepare y utilice las soluciones el mismo día. Sin embargo, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504761795
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504761795
• Sonrisas canónicas: C1C(CC(=O)C2=CN=C(N=C21)N)C3=CC=CO3
• IUPAC Name: 2-amino-7-(furan-2-yl)-7,8-dihydro-6H-quinazolin-5-one
• InChIKey: SOJUSNIBPPMLCC-UHFFFAOYSA-N
• INCHI: 1S/C12H11N3O2/c13-12-14-6-8-9(15-12)4-7(5-10(8)16)11-2-1-3-17-11/h1-3,6-7H,4-5H2,(H2,13,14,15)
• Isómeros SMILES: C1C(CC(=O)C2=CN=C(N=C21)N)C3=CC=CO3
• Peso molecular: 229.24
• Reaxy-Rn: 20627424
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20627424&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinazolines
• Alternative Parents: Aryl alkyl ketones Aminopyrimidines and derivatives Heteroaromatic compounds Furans Oxacyclic compounds Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinazoline - Aryl alkyl ketone - Aryl ketone - Aminopyrimidine - Pyrimidine - Furan - Heteroaromatic compound - Ketone - Oxacycle - Azacycle - Amine - Hydrocarbon derivative - Organic oxide - Primary amine - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

ADCY5 Tchem Adenylate cyclase type 5 (1 Activities)

Discover Target: ADCY5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADCY6 Tchem Adenylate cyclase type 6 (1 Activities)

Discover Target: ADCY6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)

Discover Target: ACP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

Discover Target: TARDBP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGR Thioredoxin glutathione reductase (28579 Activities)

Discover Target: TGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in ethanol to 10 mM (with warming) and in DMSO to 100 mM
• Sensibilidad: Light sensitive
• Peso molecular: 229.230 g/mol
• XLogP3: 0.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 229.085 Da
• Monoisotopic Mass: 229.085 Da
• Topological Polar Surface Area: 82.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 310.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, protected from light, desiccated, under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.