NRD167 , CAS No.2166487-23-4

CAS: 2166487-23-4 Cat. No.: N419999

Synonyms

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Sequence:Z-Lys(thiourea-beta-Ala-OEt)-Trp-Isopropylamine

Specifications

Sinónimos

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Mecanismos bioquímicos y fisiológicos

RD167 is the ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor (IC50 = 370 nM; <10% inhibition of SIRT1/2/3/6 at 10 μM). NRD167 exhibits anti-proliferation (IC50 = 5-8 μM) and apoptosis-induction efficacy (>80% at 5-8 μM) against SI

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C,Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Propiedades químicas y físicas

• Solubilidad: DMSO: 2 mg/mL, clear
• Sensibilidad: Light sensitive

Referencias

1. Zekun Liu, Jie Hu, Yinan Lin, Chuang Ge, Yuru Shao, Mengmeng Bao, Mengjie Liu, Shilin Jia, Yating Li, Xiaozhi Xu, Ruiyan Li, Qizhou Jiang, Fangrong Yan, Fei Xiao, Junmei Ye.  (2025)  SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.  LIVER INTERNATIONAL,  45  (12): (e70433).  [PMID:41221659] [10.1111/liv.70433]