NSC 687852 - ≥97%(HPLC) , CAS No.1009817-63-3

Name: NSC 687852 - ≥97%(HPLC) , CAS No.1009817-63-3
SKU: N286763
Availability: InStock

CAS: 1009817-63-3 Cat. No.: N286763 Fórmula: C₂₂H₁₇N₃O₆ Peso molecular: 419.39

COA

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NSC 687852 - ≥97%(HPLC) CAS No(1009817-63-3) by Aladdin Scientific

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Disponible para pedir

GRADE & PURITY ≥97%(HPLC)

Synonyms

NSC-687852 | 1-Acriloil-3,5-bis((E)-4-nitrobenciliden)piperidin-4-ona | NSC 687852 (b-AP15) | (3E,5E)-1-acriloil-3,5-bis(4-nitrobenciliden)piperidin-4-ona | DTXSID30417703 EX-A697 3,5-Bis[(4-nitrofenil)metileno]-1-(1-oxo-2-propeno-1-il)-4-piperidina-4-ona

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas Preguntas frecuentes

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Why this grade

≥97%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Conservar a -20°C Ships Hielera + almohadillas de hielo Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Una bis-nitrobencilideno-piperidinona permeable a las células que inhibe la actividad 19S deubiquitinasa (DUB) (IC50 = 2,1 µM contra la hidrólisis Ub-AMC) de forma reversible al dirigirse directamente a UCH37/UCH-L5 y USP14, mientras que muestra poca o ninguna actividad hacia BAP1, UCH-L1, UCH-L3, USP2, USP7, USP8 (IC50 >100 µM), o POH1/PRN11. La inhibición dual de UCH37 y USP14 por a-AP15 produce un aumento del nivel de ubiquitinación de proteínas celulares y un bloqueo de la degradación proteasomal de proteínas (conc. efectiva ≥770 nM en células HCT-116), exactamente lo contrario de los efectos observados con la inhibición de USP14 sola por IU1 (Nº de cat. 662210). Suprime eficazmente el crecimiento de varios tumores en ratones (2,5 a 5 mg/kg, i.p. o s.c.) in vivo.

Specifications

Sinónimos

Especificaciones y pureza

≥97%(HPLC)

Mecanismos bioquímicos y fisiológicos

In Vitro： Proteasomas 19S purificados (5 nM) se tratan con las concentraciones indicadas de b-AP15 y se determina la actividad DUB mediante la detección de la escisión de Ub-AMC. El valor IC50 (2,1±0,411 μM) se determina a partir de curvas de concentració

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Pureza

≥97%(HPLC)

Nombres e identificadores

Pubchem Sid

504763648

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504763648

Sonrisas canónicas

C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1

IUPAC Name

(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one

InChIKey

GFARQYQBWJLZMW-JYFOCSDGSA-N

INCHI

1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+

Isómeros SMILES

C=CC(=O)N1C/C(=C\C2=CC=C(C=C2)[N+](=O)[O-])/C(=O)/C(=C/C3=CC=C(C=C3)[N+](=O)[O-])/C1

Peso molecular

419.39

Reaxy-Rn

28734978

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28734978&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Clase Piperidines
    - Subclass N-acylpiperidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Clase	Piperidines
Subclass	N-acylpiperidines
Intermediate Tree Nodes	Not available
Direct Parent	N-acylpiperidines
Alternative Parents	Nitrobenzenes Nitroaromatic compounds Piperidinones Tertiary carboxylic acid amides Acrylic acids and derivatives Cyclic ketones Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	N-acyl-piperidine - Nitrobenzene - Nitroaromatic compound - Piperidinone - Monocyclic benzene moiety - Benzenoid - Acrylic acid or derivatives - Tertiary carboxylic acid amide - Carboxamide group - Ketone - C-nitro compound - Cyclic ketone - Organic nitro compound - Organic oxoazanium - Azacycle - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Carboxylic acid derivative - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
Descripción	This compound belongs to the class of organic compounds known as n-acylpiperidines. These are compounds containing an N-acyethanolamine moiety, which is characterized by an acyl group is linked to the nitrogen atom of a piperidine.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

A498 (42825 Activities)

Lot Number	Certificate Type	Fecha	Articulo
K2527162	Certificate of Analysis	Dec 13, 2025	N286763
J2129931	Certificate of Analysis	Aug 14, 2024	N286763
J2129932	Certificate of Analysis	Aug 14, 2024	N286763
J2129933	Certificate of Analysis	Aug 14, 2024	N286763

Solubilidad	insoluble in EtOH; insoluble in H2O
Peso molecular	419.400 g/mol
XLogP3	3.300
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	419.112 Da
Monoisotopic Mass	419.112 Da
Topological Polar Surface Area	129.000 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	750.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	2
Covalently-Bonded Unit Count	1

NSC 687852 - ≥97%(HPLC) , CAS No.1009817-63-3

Storage & shipping

Quality documents

Literature proof

Descripción general

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reseñas de cliente

Preguntas frecuentes

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