ON-01910 - ≥98% , CAS No.1225497-78-8

CAS: 1225497-78-8 Cat. No.: O335808 Molecular Weight: 473.43

COA

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ON-01910 - ≥98% CAS No(1225497-78-8) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

ON-01910Na | ON-019190 (sodium) | rigosertib sodium salt | ON 01910.Na | SODIUM 2-[(2-METHOXY-5-{[2-(2,4,6-TRIMETHOXYPHENYL)ETHENESULFONYL]METHYL}PHENYL)AMINO]ACETATE | Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phen

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

ON-01910 is an inhibitor to PLK1 with IC50 of 9 nM. ON-01910 also inhibits PLK2, PDGFR, Flt1, BCR-ABL, Fyn, Src, and CDK1, with IC50 of 18–260 nM. ON-01910 shows cell killing activity against 94 different tumor cell lines with IC50 of 50–250 nM, including BT27, MCF-7, DU145, PC3, U87, A549, H187, RF1, HCT15, SW480, and KB cells. In HeLa cells, ON-01910 (100–250 nM) induces spindle abnormalities and apoptosis. ON-01910 also inhibits several multidrug resistant tumor cell lines.

Specifications

Synonyms

ON-01910Na | ON-019190 (sodium) | rigosertib sodium salt | ON 01910.Na | SODIUM 2-[(2-METHOXY-5-{[2-(2, 4, 6-TRIMETHOXYPHENYL)ETHENESULFONYL]METHYL}PHENYL)AMINO]ACETATE | Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2, 4, 6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phen

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

Pubchem Sid	504769691
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769691
Canonical Smiles	COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
IUPAC Name	sodium;2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetate
InChIKey	VLQLUZFVFXYXQE-USRGLUTNSA-M
INCHI	1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
Isomeric SMILES	COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
Molecular Weight	473.43
Reaxy-Rn	26934487
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26934487&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent	Alpha amino acids
Alternative Parents	Aminophenyl ethers Methoxyanilines Styrenes Phenylalkylamines Phenoxy compounds Anisoles Methoxybenzenes Secondary alkylarylamines Alkyl aryl ethers Sulfones Amino acids Carboxylic acid salts Carboxylic acids Monocarboxylic acids and derivatives Hydrocarbon derivatives Organopnictogen compounds Carbonyl compounds Organic sodium salts Organic zwitterions Organic oxides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Alpha-amino acid - Methoxyaniline - Aminophenyl ether - Styrene - Aniline or substituted anilines - Phenylalkylamine - Phenol ether - Methoxybenzene - Anisole - Phenoxy compound - Alkyl aryl ether - Secondary aliphatic/aromatic amine - Monocyclic benzene moiety - Benzenoid - Sulfonyl - Sulfone - Carboxylic acid salt - Amino acid - Carboxylic acid - Ether - Monocarboxylic acid or derivatives - Organic alkali metal salt - Secondary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Amine - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic sodium salt - Organic salt - Organic zwitterion - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGS (1999 Activities)

Lot Number	Certificate Type	Date	Item
C2625012	Certificate of Analysis	Apr 06, 2026	O335808
E2213017	Certificate of Analysis	Feb 07, 2025	O335808
E2213018	Certificate of Analysis	Feb 07, 2025	O335808
E2213024	Certificate of Analysis	Feb 07, 2025	O335808
E2213025	Certificate of Analysis	Feb 07, 2025	O335808

Solubility	≥23.65 mg/mL in DMSO; insoluble in EtOH; ≥52.3 mg/mL in H2O
Molecular Weight	473.500 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	11
Exact Mass	473.112 Da
Monoisotopic Mass	473.112 Da
Topological Polar Surface Area	132.000 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	684.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	2