2mM in Water for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 49 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin , the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin or Carboplatin , and shows antitumor activity in cell lines with acquired Cisplatin resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently.
A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines
Product class
hAPIs, Metal based hAPIs
Chemical properties
C8H14N2O4Pt
[Pt((R,R)-dach)(ox)]
397.28
Pt
49
powder
white
| Pubchem Sid | 528771335 |
|---|---|
| Sonrisas canónicas | C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2] |
| InChIKey | ZROHGHOFXNOHSO-BNTLRKBRSA-L |
| INCHI | 1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1 |
| Isómeros SMILES | C1CC[C@H]([C@@H](C1)[NH-])[NH-].C(=O)(C(=O)O)O.[Pt+2] |
| WGK Alemania | 3 |
| RTECS | TP2275850 |
| Peso molecular | 397.29 |
| Reaxy-Rn | 14621501 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic nitrogen compounds |
| Clase | Organonitrogen compounds |
| Subclass | Cyclohexylamines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Cyclohexylamines |
| Alternative Parents | Dicarboxylic acids and derivatives Organic transition metal salts Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Not available |
| Substituents | Cyclohexylamine - Dicarboxylic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Organic transition metal salt - Amine - Organic salt - Primary amine - Organooxygen compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aliphatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as cyclohexylamines. These are organic compounds containing a cyclohexylamine moiety, which consist of a cyclohexane ring attached to an amine group. |
| External Descriptors | platinum coordination entity |
| Sensibilidad | Heat Sensitive |
|---|---|
| Peso molecular | 397.290 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 0 |
| Exact Mass | 397.06 Da |
| Monoisotopic Mass | 397.06 Da |
| Topological Polar Surface Area | 76.600 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 191.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 3 |
I2608684