P7C3 - ≥98% , CAS No.301353-96-8

CAS: 301353-96-8 Cat. No.: P275159 Molecular Weight: 474.19 EC Number: 685-988-7 PubChem CID: 2836187

GRADE & PURITY ≥98%

Synonyms

AKOS016344050 | SR-01000414355-1 | BCP09423 | DTXSID70385472 | SCHEMBL410147 | 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol | HY-15976 | J-017798 | 9H-CARBAZOLE-9-ETHANOL, 3,6-DIBROMO-.ALPHA.-((PHENYLAMINO)METHYL)- | 1-(3,6-Dibromo-carbazol

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

 Product Application：

P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.

Specifications

Synonyms

AKOS016344050 | SR-01000414355-1 | BCP09423 | DTXSID70385472 | SCHEMBL410147 | 1-(3, 6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol | HY-15976 | J-017798 | 9H-CARBAZOLE-9-ETHANOL, 3, 6-DIBROMO-.ALPHA.-((PHENYLAMINO)METHYL)- | 1-(3, 6-Dibromo-carbazol

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Pro-neurogenic and neuroprotective compound. Blocks apoptosis of newborn neurons of the dentate gyrus. Also protects mature neurons. Enhances neurogenesis and additionally improves cognitive behaviour. Blood-brain barrier permeable. Active in vivo .

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504762231
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504762231
• Canonical Smiles: C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O
• IUPAC Name: 1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol
• InChIKey: FZHHRERIIVOATI-UHFFFAOYSA-N
• INCHI: 1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
• Isomeric SMILES: C1=CC=C(C=C1)NCC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)O
• PubChem CID: 2836187
• Molecular Weight: 474.19

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives
        • Level5 Brominated biphenyls
          • Level6 Polybrominated biphenyls

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Brominated biphenyls
• Direct Parent: Polybrominated biphenyls
• Alternative Parents: Carbazoles N-alkylindoles Indoles Phenylalkylamines Aniline and substituted anilines Secondary alkylarylamines Substituted pyrroles Aryl bromides Heteroaromatic compounds Secondary alcohols 1,2-aminoalcohols Azacyclic compounds Organopnictogen compounds Organobromides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Polybrominated biphenyl - Carbazole - N-alkylindole - Indole - Indole or derivatives - Phenylalkylamine - Aniline or substituted anilines - Secondary aliphatic/aromatic amine - Aryl bromide - Substituted pyrrole - Aryl halide - Heteroaromatic compound - Pyrrole - Secondary alcohol - 1,2-aminoalcohol - Azacycle - Organoheterocyclic compound - Secondary amine - Organopnictogen compound - Organobromide - Organohalogen compound - Alcohol - Organonitrogen compound - Organic nitrogen compound - Organooxygen compound - Organic oxygen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as polybrominated biphenyls. These are organic aromatic compounds containing a biphenyl moiety, which is substituted at two or more ring positions by a bromine atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NSC (149 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in DMSO to 100 mM
• Sensitivity: Light sensitive
• Molecular Weight: 474.200 g/mol
• XLogP3: 5.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 473.977 Da
• Monoisotopic Mass: 471.979 Da
• Topological Polar Surface Area: 37.200 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 433.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1