Palovarotene - 10mM in DMSO , Retinoic acid receptor gamma agonist, CAS No.410528-02-8, Retinoic acid receptor gamma agonist

CAS: 410528-02-8 Cat. No.: P655848 Fórmula: C₂₇H₃₀N₂O₂ Peso molecular: 414.54 PubChem CID: 10295295

CALIDAD & PUREZA 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Palovarotene is a nuclear retinoic acid receptor γ ( RAR-γ ) agonist.

In Vivo

Palovarotene suppresses post-traumatic chondrogenesis and osteogenesis and mitigated trauma-induced ectopic bone formation. Palovarotene inhibits subcutaneous and intramuscular heterotopic ossification (HO) in mice. Palovarotene is given orally for 14 days at 1 mg/kg/day starting on post-operative day (POD) 1 or POD-5, and HO amount, wound dehiscence and related processes are monitored for up to 84 days post injury. Compared to vehicle-control animals, Palovarotene significantly decreases HO by 50 to 60% regardless of when the treatment started and if infection is present . Starting from day 1 of injury, half of the Acvr1 cR206H/+ mice are treated with Palovarotene by daily gavage for 14 days and the other half received vehicle as control. Analysis by mCT and 3D image reconstruction at day 14 shows that large HO tissue masses have formed in the targeted leg of Acvr1 cR206H/+ mutant mice receiving vehicle, but HO formation is greatly diminished in Palovarotene-treated companions by more than 80% based on bone volume/total volume quantification. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:RAR-γ

Especificaciones

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Palovarotene is a nuclear retinoic acid receptor γ ( RAR-γ ) agonist.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

AGONIST

Mecanismo de acción

Retinoic acid receptor gamma agonist

Propiedades del producto

ALogP

6.8

Nombres e identificadores

Isómeros SMILES

CC1(CCC(C2=C1C=C(C(=C2)/C=C/C3=CC=C(C=C3)C(=O)O)CN4C=CC=N4)(C)C)C

CAS alternativo

410528-02-8

PubChem CID

10295295

Términos de entrada MeSH

Palovarotene;R-667;RG-667;RO-3300074

Peso molecular

414.54

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 410528-02-8, the molecular formula is C27H30N2O2, and the molecular weight is 414.54 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.