Pargyline - Moligand™, 10 mM in DMSO , CAS No.555-57-7

CAS: 555-57-7 Cat. No.: P1499271 Molecular Weight: 159.23 EC Number: 209-101-6

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K i s of 13 μM and 0.5 μM for MAO-A and MAO-B , respectively. Pargyline has antihypertensive and anticancer activities. Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: CN(CC#C)CC1=CC=CC=C1
• WGK Germany: 3
• RTECS: DP6475000
• Molecular Weight: 159.23
• Reaxy-Rn: 1938132
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1938132&ln=

Chemical and Physical Properties

• Refractive Index: 1.522
• Flash Point(°F): 183.2 °F
• Flash Point(°C): 84°C
• Boil Point(°C): 86-88 °C/4 mmHg

References

1. Xiaodong Guo, Jundan Yi, Zhuqing Wan, Xin Wang, Zhiruo Yuan, Waisze Cheung, Xiaoqiang Bai, Yang Fu, Mo Zhai, Longwei Lv, Yongsheng Zhou.  (2025)  Morphology and Function Dual-Adjustable Biomimetic 4D-Printed Scaffold for the Regenerative Restoration of Complex Bone Defects.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202509961]

2. Changjun Zhang, Ke Yang, Sihang Yu, Jing Su, Shengli Yuan, Jiaxin Han, Yan Chen, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie.  (2019)  Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:31325784] [10.1016/j.ejmech.2019.07.031]

3. Xiaoying Jiang, Jianan Guo, Yangjing Lv, Chuansheng Yao, Changjun Zhang, Zhisheng Mi, Yuan Shi, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie.  (2020)  Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity.  BIOORGANIC & MEDICINAL CHEMISTRY,      [PMID:32503694] [10.1016/j.bmc.2020.115550]

4. Xi Zhu, Yangjing Lv, Miaoliang Fan, Jianan Guo, Yujia Zhang, Bianbian Gao, Changjun Zhang, Yuanyuan Xie.  (2023)  Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer’s disease.  BIOORGANIC CHEMISTRY,      [PMID:37690318] [10.1016/j.bioorg.2023.106817]

5. Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie.  (2023)  Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease.  JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,      [PMID:36519319] [10.1080/14756366.2022.2134358]

6. Chuansheng Yao, Xiaoying Jiang, Rui Zhao, Zhichao Zhong, Jiamin Ge, Junlong Zhu, Xiang-Yang Ye, Yuanyuan Xie, Zhen Liu, Tian Xie, Renren Bai.  (2022)  HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids.  BIOORGANIC CHEMISTRY,      [PMID:35305483] [10.1016/j.bioorg.2022.105724]

7. Ting Cao, Mengjin Li, Hong Ma, Zhefeng Fan.  (2026)  Visualization of mitochondrial monoamine oxidase dynamics in live cells and DILI via a ratiometric NIR probe with “ICT+ESIPT” mechanism.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:41759435] [10.1016/j.saa.2026.127639]