PD128907 HCl - 10mM in DMSO , CAS No.112960-16-4

CAS: 112960-16-4 Cat. No.: P408979 Fórmula: C₁₄H₁₉NO₃·HCl Peso molecular: 285.77

GRADE & PURITY 10mM in DMSO

Synonyms

2H,5H-[1]Benzopyrano[4,3-b]-1,4-oxazin-9-ol, 3,4,4a,10b-tetrahydro-4-propyl-, hydrochloride (1:1), (4aR,10bR)-rel-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

PD 128907 HCl is a potent and selectivedopamine D3 receptoragonist, withEC50of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
In vitro

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. When using [³H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (K_i, 1 nM) versus human D2 receptors (K_i, 1183 nM) and a l0000-fold selectivity versus human D4receptors (K_i, 7000 nM) PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release.

In vivo

PD 128907 is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. PD 128907 (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

2H,5H-[1]Benzopyrano[4,3-b]-1,4-oxazin-9-ol, 3,4,4a,10b-tetrahydro-4-propyl-, hydrochloride (1:1), (4aR,10bR)-rel-

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Isómeros SMILES: CCCN1CCO[C@H]2[C@H]1COC3=C2C=C(C=C3)O.Cl
• WGK Alemania: 3
• Peso molecular: 285.77
• Reaxy-Rn: 37356230
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37356230&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 112960-16-4, the molecular formula is C14H20ClNO3, and the molecular weight is 285.77 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.