Pomalidomide-C₆-CO₂H - ≥98% , CAS No.2225940-50-9

CAS: 2225940-50-9 Cat. No.: P464854 Fórmula: C₂₀H₂₃N₃O₆ Peso molecular: 401.42 PubChem CID: 134589631

GRADE & PURITY ≥98%

Synonyms

Protein degrader building block for PROTAC research, 7-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanoic acid, Crosslinker−E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Description

Protein degrader builiding block Pomalidomide-C6-CO2H enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinónimos

Protein degrader building block for PROTAC research, 7-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)heptanoic acid, Crosslinker−E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader

Especificaciones y pureza

≥98%

Información jurídica

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

Sonrisas canónicas

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCC(=O)O

IUPAC Name

7-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]heptanoic acid

InChIKey

USOIUAJFCJMMOE-UHFFFAOYSA-N

INCHI

1S/C20H23N3O6/c24-15-10-9-14(18(27)22-15)23-19(28)12-6-5-7-13(17(12)20(23)29)21-11-4-2-1-3-8-16(25)26/h5-7,14,21H,1-4,8-11H2,(H,25,26)(H,22,24,27)

PubChem CID

134589631

Peso molecular

401.42

Propiedades químicas y físicas

• Peso molecular: 401.400 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 401.159 Da
• Monoisotopic Mass: 401.159 Da
• Topological Polar Surface Area: 133.000 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 694.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1