PQ-10 - ≥99% , CAS No.927691-21-2

CAS: 927691-21-2 Cat. No.: P651532 Fórmula: C₂₂H₂₁N₅O₃ Peso molecular: 403.43 PubChem CID: 11704101

CALIDAD & PUREZA ≥99%

Synonyms

A 844337 | AKOS037643512 | 6,7-DIMETHOXY-4-[3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE | PQ10 | NCGC00402348-02 | AS-16700 | A844337 | A-844337 | PQ 10 | DTXSID10470891 | 6,7-dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline | 6,7-dimeth

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

PQ-10 is a potent inhibitor of Phosphodiesterase 10A ( PDE10A ) with IC 50 and ED 50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia

In Vivo

PQ-10 shows region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 24 –28 g male C57BL/6 mice, PDE10A WT and KO mice Dosage: 0.16, 0.63, 2.5, and 10 mg/kg Administration: s.c. Result: Showed region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice.

Form:Solid

IC50& Target:PDE10A 4.6 nM (IC 50 )

Especificaciones

Sinónimos

A 844337 | AKOS037643512 | 6,7-DIMETHOXY-4-[3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE | PQ10 | NCGC00402348-02 | AS-16700 | A844337 | A-844337 | PQ 10 | DTXSID10470891 | 6,7-dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline | 6,7-dimeth

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

PQ-10 is a potent inhibitor of Phosphodiesterase 10A ( PDE10A ) with IC 50 and ED 50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for res

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥99%

Nombres e identificadores

Sonrisas canónicas

COC1=C(C=C2C(=C1)C(=NC=N2)N3CCC(C3)OC4=NC5=CC=CC=C5N=C4)OC

IUPAC Name

6,7-dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline

InChIKey

UBIIFKJMNRPNMT-UHFFFAOYSA-N

INCHI

1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3

Isómeros SMILES

COC1=C(C=C2C(=C1)C(=NC=N2)N3CCC(C3)OC4=NC5=CC=CC=C5N=C4)OC

WGK Alemania

3

PubChem CID

11704101

Peso molecular

403.43

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Diazanaphthalenes
      • Subclass Benzodiazines
        • Level5 Quinazolines
          • Level6 Quinazolinamines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Quinazolines
• Direct Parent: Quinazolinamines
• Alternative Parents: Quinoxalines Dialkylarylamines Anisoles Aminopyrimidines and derivatives Alkyl aryl ethers Pyrazines Imidolactams Pyrrolidines Heteroaromatic compounds Azacyclic compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinazolinamine - Quinoxaline - Anisole - Phenol ether - Dialkylarylamine - Alkyl aryl ether - Aminopyrimidine - Pyrazine - Imidolactam - Benzenoid - Pyrimidine - Heteroaromatic compound - Pyrrolidine - Ether - Azacycle - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PDE10A Tclin cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (0 Activities)

Discover Target: PDE10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3A Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase A (0 Activities)

Discover Target: PDE3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE3B Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase B (0 Activities)

Discover Target: PDE3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: DMSO : 25 mg/mL (50.64 mM; Need ultrasonic)
• Peso molecular: 403.400 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 403.164 Da
• Monoisotopic Mass: 403.164 Da
• Topological Polar Surface Area: 82.500 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 569.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 927691-21-2, the molecular formula is C22H21N5O3, and the molecular weight is 403.43 g/mol. InChIKey UBIIFKJMNRPNMT-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.