Pramipexole 2HCl Monohydrate - ≥98%(HPLC) , D2-like dopamine receptor agonist, CAS No.191217-81-9, D2-like dopamine receptor agonist

CAS: 191217-81-9 Cat. No.: P129443 Fórmula: C₁₀H₁₇N₃S·2HCl·H₂O Peso molecular: 302.26 Número EC: 687-708-9 PubChem CID: 166589

GRADE & PURITY ≥98%(HPLC)

Synonyms

PRAMIPEXOLE DIHYDROCHLORIDE [USP MONOGRAPH] | SCHEMBL25118 | CCG-267486 | Mirapex (TN) | PRAMIPEXOLE HYDROCHLORIDE HYDRATE [JAN] | Pramipexole Hydrochloride Monohydrate | T72003 | UNII-3D867NP06J | D00559 | s2011 | HY-B0410A | APVQOOKHDZVJEX-QTPLPEIMSA-N

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Pramipexole 2HCl Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.
A non-ergoline dopamine agonist.

Specifications

Sinónimos

PRAMIPEXOLE DIHYDROCHLORIDE [USP MONOGRAPH] | SCHEMBL25118 | CCG-267486 | Mirapex (TN) | PRAMIPEXOLE HYDROCHLORIDE HYDRATE [JAN] | Pramipexole Hydrochloride Monohydrate | T72003 | UNII-3D867NP06J | D00559 | s2011 | HY-B0410A | APVQOOKHDZVJEX-QTPLPEIMSA-N

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Pramipexole is a dopamine agonist active at D3 and D2 receptor subtypes. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibit

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

AGONIST

Mecanismo de acción

D2-like dopamine receptor agonist

Nota

Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%(HPLC)

Nombres e identificadores

Pubchem Sid

504757593

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504757593

Sonrisas canónicas

CCCNC1CCC2=C(C1)SC(=N2)N.O.Cl.Cl

IUPAC Name

(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;hydrate;dihydrochloride

InChIKey

APVQOOKHDZVJEX-QTPLPEIMSA-N

INCHI

1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1

Isómeros SMILES

CCCN[C@H]1CCC2=C(C1)SC(=N2)N.O.Cl.Cl

CAS alternativo

191217-81-9

PubChem CID

166589

Términos de entrada MeSH

2 Amino 6 propylaminotetrahydrobenzothiazole;2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole;2-amino-6-propylaminotetrahydrobenzothiazole;4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine;6,7-tetrahydro-N6-propyl-2,6-benzothiazolediamine dihydr

Peso molecular

302.26

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Clase Organonitrogen compounds
      • Subclass Amines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Clase: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Not available
• Direct Parent: Aralkylamines
• Alternative Parents: 2-amino-1,3-thiazoles Heteroaromatic compounds Dialkylamines Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aralkylamine - 1,3-thiazol-2-amine - Azole - Thiazole - Heteroaromatic compound - Secondary aliphatic amine - Secondary amine - Azacycle - Organoheterocyclic compound - Organic oxygen compound - Hydrochloride - Hydrocarbon derivative - Organic oxide - Primary amine - Organopnictogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
• External Descriptors: hydrate

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in water (61 mg/ml at 25 °C), DMSO (41 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
• Rotación específica [α]: -67° (C=1,MeOH)
• Punto de fusión (°C): 296-305°C
• Peso molecular: 302.300 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 301.078 Da
• Monoisotopic Mass: 301.078 Da
• Topological Polar Surface Area: 80.200 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 188.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

XLogP3