GRADE & PURITYBioReagent?BioReagent grade — tested suitable for life-science and molecular-biology use. Use for cell culture, assays, and biochemical work needing biological compatibility.Native?Native grade — protein/biomolecule in its natural (non-recombinant, non-denatured) form. Use when native structure and activity are required.≥95%(SDS-PAGE)from Human plasma; Pre-lyophilization Protein Concentration: See COA
BioReagent, Native, ≥95%(SDS-PAGE), from Human plasma; Pre-lyophilization Protein Concentration: See COA BioReagent,Native for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography. The protein purity is determined by SDS-PAGE and shows total reduction upon incubation with 2-mercaptoethanol. Protein C is activated to the serine protease, Activated Protein C (APC), by a-thrombin or the complex of a-thrombin/thrombomodulin and is a potent anticoagulant through the selective inactivation of Factors Va and VIIIa.
Buffer composition = 20 mM Tris-HCl/0.1 M NaCl/1 mM Benzamidine/pH 7.4
Extinction Coefficient (1%) = 14.5
Molecular Weight = 62,000 daltons
The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.
Specifications
Product Name
Protein C (PC), CAS No.925910-74-3
Grade
BioReagent, Native
Specifications & Purity
BioReagent, Native, ≥95%(SDS-PAGE), from Human plasma; Pre-lyophilization Protein Concentration: See COA
Biochemical and Physiological Mechanisms
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Miscellaneous:
from Human plasma; Pre-lyophilization Protein Concentration: See COA
Reconstitution
We suggest hydrating the protein with a good quality water to the original volume (See COA). After hydration aliquot into a useful (one time use) size and freeze at -80℃.
Storage
Store at 2-8°C
Shipped In
Wet ice
Stability And Storage
Store at 2-8℃ long term. Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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