RG7112 - Moligand™, ≥98% , Inhibitor of MDM2 proto-oncogene, CAS No.939981-39-2, Inhibitor of MDM2 proto-oncogene

CAS: 939981-39-2 Cat. No.: R127149 Fórmula: C38H48Cl2N4O4S Peso molecular: 727.78 PubChem CID: 57406853
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
DTXSID60240182 | CCG-270414 | EX-A1686 | UNII-Q8MI0X869M | RG7112 (RO5045337) | Q27287118 | R 7112 | R 7112 [WHO-DD] | RG-7112;RG 7112; RO-5045337; RO 5045337; RO5045337 | AKOS027282701 | Ro 5045337 | s7030 | A857519 | HY-10959 | METHANONE, ((4S,5R)-4,5-B
Storage
Conservar a -20°C
Shipped In
Hielera + almohadillas de hielo
★
Size
Alemania (EU)
USA*
Price
Qty
5mg
R127149-5mg
—
3 Disponible

41,56€

62,39€
Guardar 20,83 € (33.38%)
10mg
R127149-10mg
—
2 Disponible

75,41€

113,59€
Guardar 38,18 € (33.61%)
25mg
R127149-25mg
—
2 Disponible

106,65€

160,44€
Guardar 53,80 € (33.53%)
50mg
R127149-50mg
—
1 Disponible

180,40€

270,65€
Guardar 90,24 € (33.34%)
100mg
R127149-100mg
—
2 Disponible

306,23€

459,81€
Guardar 153,59 € (33.40%)
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Conservar a -20°C Ships Hielera + almohadillas de hielo Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Sinónimos
DTXSID60240182 | CCG-270414 | EX-A1686 | UNII-Q8MI0X869M | RG7112 (RO5045337) | Q27287118 | R 7112 | R 7112 [WHO-DD] | RG-7112;RG 7112; RO-5045337; RO 5045337; RO5045337 | AKOS027282701 | Ro 5045337 | s7030 | A857519 | HY-10959 | METHANONE, ((4S,5R)-4,5-B
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
La restauración de la actividad de p53 mediante la inhibición de la interacción p53-MDM2 puede representar un enfoque novedoso para el tratamiento del cáncer. RG7112 es el primer inhibidor clínico de MDM2 de molécula pequeña diseñado para ocupar el bolsil
Condiciones de almacenamiento de almacenamiento
Conservar a -20°C
Enviado en
Hielera + almohadillas de hielo
Grado
Moligand™
Tipo de acción
INHIBITOR
Mecanismo de acción
Inhibitor of MDM2 proto-oncogene
Nota
Siempre que sea posible, prepare y utilice las soluciones el mismo día. Sin embargo, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.
Pureza
≥98%
Nombres e identificadores
Pubchem Sid504771595
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504771595
Sonrisas canónicasCCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
IUPAC Name[(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone
InChIKeyQBGKPEROWUKSBK-QPPIDDCLSA-N
INCHI1S/C38H48Cl2N4O4S/c1-8-48-33-26-29(36(2,3)4)14-19-32(33)34-41-37(5,27-10-15-30(39)16-11-27)38(6,28-12-17-31(40)18-13-28)44(34)35(45)43-23-21-42(22-24-43)20-9-25-49(7,46)47/h10-19,26H,8-9,20-25H2,1-7H3/t37-,38+/m0/s1
Isómeros SMILES CCOC1=C(C=CC(=C1)C(C)(C)C)C2=N[C@@]([C@@](N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
CAS alternativo 939981-39-2
PubChem CID 57406853
Términos de entrada MeSH RG7112
Peso molecular 727.78

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClaseStilbenes
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentStilbenes
Alternative Parents Piperazine carboxamides  Phenylpropanes  Phenoxy compounds  Phenol ethers  Alkyl aryl ethers  Chlorobenzenes  N-alkylpiperazines  Aryl chlorides  Sulfones  Imidazolines  Ureas  Trialkylamines  Propargyl-type 1,3-dipolar organic compounds  Azacyclic compounds  Carboxamidines  Carboximidamides  Organochlorides  Carbonyl compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Stilbene - Phenylpropane - Piperazine-1-carboxamide - Phenol ether - Phenoxy compound - Alkyl aryl ether - Chlorobenzene - Halobenzene - N-alkylpiperazine - Benzenoid - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Piperazine - 1,4-diazinane - Sulfonyl - Sulfone - 2-imidazoline - Urea - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Carboxylic acid amidine - Amidine - Ether - Carbonyl group - Organic oxide - Hydrocarbon derivative - Amine - Organic oxygen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
MDM2 Tchem E3 ubiquitin-protein ligase Mdm2 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MDM2 Tchem p53-binding protein Mdm-2 (4545 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RKO (1376 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SW480 (6023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsomes (16955 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SJSA-1 (970 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeFechaArticulo
I2227571Certificate of AnalysisApr 03, 2026 R127149
I2227579Certificate of AnalysisApr 03, 2026 R127149
I2227580Certificate of AnalysisApr 03, 2026 R127149
I2227581Certificate of AnalysisApr 03, 2026 R127149
I2227582Certificate of AnalysisApr 03, 2026 R127149
Propiedades químicas y físicas
SolubilidadDMSO
Peso molecular727.800 g/mol
XLogP37.300
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count10
Exact Mass726.277 Da
Monoisotopic Mass726.277 Da
Topological Polar Surface Area90.900 Ų
Heavy Atom Count49
Formal Charge0
Complexity1260.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluciones
Reseñas

Reseñas de cliente

Preguntas frecuentes

What is the purity of this product?
This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 939981-39-2, the molecular formula is C38H48Cl2N4O4S, and the molecular weight is 727.78 g/mol. InChIKey QBGKPEROWUKSBK-QPPIDDCLSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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