RO-28-1675 - 10mM in DMSO , CAS No.300353-13-3

CAS: 300353-13-3 Cat. No.: R656490 Fórmula: C₁₈H₂₂N₂O₃S₂ Peso molecular: 378.51

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC 50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes

In Vitro

RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RO-28-1675 (50 mg/kg; p.o.) reduces blood glucose levels in wild-type C57BL/6J mice. RO-28-1675 exhibits high oral bioavailability (mice 92.8%) and C max (1140 μg/mL) following oral administration (10 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 10 weeks old male C57BL/6J miceDosage: 50 mg/kg Administration: Oral administration Result: Reduced blood glucose levels. Animal Model: C57BL/6J mice Dosage: 10 mg/kg (Pharmacokinetic Analysis Administration: Oral administration Result: Oral bioavailability (92.8%), C max (1140 μg/mL), T max (3.3 h).

IC50& Target:EC50: 54 nM (glucokinase)

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC 50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Peso molecular: 378.51