RO0270608 - 10mM in DMSO , CAS No.220846-33-3

CAS: 220846-33-3 Cat. No.: R654494 Molecular Weight: 505.78 PubChem CID: 16727128

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity

In Vitro

RO0270608 inhibits α4/β7 mediated cell adhesion with an IC50 of 33 nM. In a human T-cell VCAM/anti CD3 costimulation assay RO0270608 causes a pronounced inhibition of T-cell proliferation (IC 50 =30 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulationMCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:α4β1 α4β7

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist . Antiinflammatory activity.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC1=C(C(=CC=C1)Cl)C(=O)N[C@@H](CC2=CC=C(C=C2)NC(=O)C3=C(C=CC=C3Cl)Cl)C(=O)O
• PubChem CID: 16727128
• Molecular Weight: 505.78