(S)-(+)-Ibuprofen - Moligand™, 10 mM in DMSO , CAS No.51146-56-6

CAS: 51146-56-6 Cat. No.: S1499229 Molecular Weight: 206.28 Beilstein Registry Number: 3590022 EC Number: 610-620-9

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC 50 s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects .

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Product Properties

• ALogP: 3.5

Names and Identifiers

• Isomeric SMILES: C[C@@H](C1=CC=C(C=C1)CC(C)C)C(=O)O
• WGK Germany: 3
• Molecular Weight: 206.28
• Beilstein: 3590022
• Reaxy-Rn: 2049713
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2049713&ln=

Chemical and Physical Properties

• Specific Rotation[α]: 59°
• Flash Point(°F): >235.4 °F
• Flash Point(°C): >113 °C
• Melt Point(°C): 49-53°C

References

1. Lumei Dai, Shifang Wen, Yaling Chen, Xinchun Li, Bing Zhao, Xinyu You, Rongqiang Li, Bin Zhang.  (2025)  Self-assembled dual-target ibuprofen-irinotecan conjugate for colorectal cancer therapy.  BIOORGANIC & MEDICINAL CHEMISTRY,      [PMID:40850193] [10.1016/j.bmc.2025.118367]

2. Dan Xiao, Ying Jin, Mengyu Zhang, Xiangjie Di, Lisha Fu, Changke Jiang, Zhuoli Lai, Yating Ge, Shanmian Ji, Yuming Zhang, Li Zheng, Zhenlei Wang, Fang Gong.  (2023)  Chiral pharmacokinetics of ibuprofen enantiomers in Chinese preterm neonates with patent ductus arteriosus using a validated UHPLC-MS/MS method.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:37454407] [10.1016/j.jchromb.2023.123765]

3. Zhenfei Wang, Bin Liang, Yanan Hou, Si Li, Li Xie, Liang Peng, Peng Zhang, Aijie Wang, Hui Yun, Xiangkai Li.  (2022)  Weak electrostimulation enhanced the microbial transformation of ibuprofen and naproxen.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:35489501] [10.1016/j.scitotenv.2022.155522]

4. Zefang Wang, Yan Peng, Chengjun Shi, Liping Wang, Xiaohong Chen, Wanwan Wu, Xu Wu, Yiming Zhu, Jingchen Zhang, Guiliang Cheng, Songlin Zhuang.  (2021)  Qualitative and quantitative recognition of chiral drugs based on terahertz spectroscopy.  ANALYST,  146  (12): (3888-3898).  [PMID:34042921] [10.1039/D1AN00500F]

5. Qian Han, Cun Wang, Pingkun Liu, Gui Zhang, Li Song, Yingzi Fu.  (2021)  Achieving synergistically enhanced dual-mode electrochemiluminescent and electrochemical drug sensors via a multi-effect porphyrin-based metal-organic framework.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2020.129388]

6. Fang Wang, Bin Wang, Han Qu, Wenxing Zhao, Lei Duan, Yizhe Zhang, Yitong Zhou, Gang Yu.  (2020)  The influence of nanoplastics on the toxic effects, bioaccumulation, biodegradation and enantioselectivity of ibuprofen in freshwater algae Chlorella pyrenoidosa.  ENVIRONMENTAL POLLUTION,      [PMID:32315820] [10.1016/j.envpol.2020.114593]

7. Mingxia Liu, Lixia Chen, Tingting Tian, Zhiguo Zhang, Xiangjun Li.  (2019)  Identification and Quantitation of Enantiomers by Capillary Electrophoresis and Circular Dichroism Independent of Single Enantiomer Standard.  ANALYTICAL CHEMISTRY,      [PMID:31591882] [10.1021/acs.analchem.9b03276]

8. Tuanjia Li, Wangchuan Xiao, Shizhao Ren, Rongrong Xue, Fenghua Chen.  (2024)  Metastable Racemic Ibuprofen Supercooled Liquid.  Crystals,  14  (12): (1037).  [PMID:] [10.3390/cryst14121037]

9. Duo Xu, Yantian Ji, Bowen Du, Bo He, Hongyang Chen, Huimin Sun, Xianqiang Yin.  (2024)  The synergistic effect of typical chiral organic acids and solution chemistry conditions on the transport of 2-arylpropionic acid chiral derivatives in porous media.  ENVIRONMENTAL POLLUTION,      [PMID:38703979] [10.1016/j.envpol.2024.124059]