Salubrinal - 10mM in DMSO , CAS No.405060-95-9

CAS: 405060-95-9 Cat. No.: S408834 Fórmula: C₂₁H₁₇Cl₃N₄OS Peso molecular: 479.81 Número EC: 809-398-8 PubChem CID: 5717801

GRADE & PURITY 10mM in DMSO

Synonyms

2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. Salubrinal increased non-rapid eye movement (NREM) sleep.

In vivo

Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response.
Cell Data

cell lines：HCT-116 and WSU-DLCL2 cells

Concentrations：0-100 μM

Incubation Time：48 hours

Powder Purity:≥98%

Specifications

Sinónimos

2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
• WGK Alemania: 3
• PubChem CID: 5717801
• Peso molecular: 479.81

Referencias

1. Liang Chen, Guo Liping, Tian Xinyan, Mu Zhidan, Chen Mingyang, Hu Yarong, Su Juan.  (2025)  The interaction between COX-2 and endoplasmic reticulum stress is involved in liver ischemia–reperfusion injury in mice.  MOLECULAR BIOLOGY REPORTS,  52  (1): (1-14).  [PMID:40663274] [10.1007/s11033-025-10814-7]

Preguntas frecuentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 405060-95-9, the molecular formula is C21H17Cl3N4OS, and the molecular weight is 479.81 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.