Sauchinone - ≥98% , CAS No.177931-17-8

CAS: 177931-17-8 Cat. No.: S335795 Fórmula: C₂₀H₂₀O₆ Peso molecular: 356.37 PubChem CID: 11725801

CALIDAD & PUREZA ≥98%

Synonyms

sauchinone | SCHEMBL1498622 | AS-77171 | MFCD08702698 | AKOS030631736 | AC-34741 | J-011331 | (1S,12R,13S,14R,16R,23R)-13,14-dimethyl-2,6,8,20,22-pentaoxahexacyclo[10.10.1.01,19.03,11.05,9.016,23]tricosa-3,5(9),10,18-tetraen-17-one | s9406 | CCG-268111 |

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Sauchinone is a diastereomeric ligand with cytoprotective and antioxidant activities in cultured hepatocytes. Sauchinone is an inhibitor of LPS-inducible iNOS (NOS II), TNF-α and Cox-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Sauchinone also acts as a suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit and inhibits staurosporine-induced apoptosis. Sauchinone inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.

Especificaciones

Sinónimos

sauchinone | SCHEMBL1498622 | AS-77171 | MFCD08702698 | AKOS030631736 | AC-34741 | J-011331 | (1S,12R,13S,14R,16R,23R)-13,14-dimethyl-2,6,8,20,22-pentaoxahexacyclo[10.10.1.01,19.03,11.05,9.016,23]tricosa-3,5(9),10,18-tetraen-17-one | s9406 | CCG-268111 |

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Sauchinone is an anti-inflammatory and antioxidant lignan isolated from Saururus chinensis a medical plant used for the treatment of fever, jaundice, oedema and inflammatory disease in oriental folk medicine. Sauchinone inhibits LPS-inducible iNOS (NOS II

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C

Enviado en

Ice chest + Ice pads

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Pureza

≥98%

Nombres e identificadores

Pubchem Sid

488197681

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488197681

Sonrisas canónicas

CC1CC2C3C(C1C)C4=CC5=C(C=C4OC36C(=CC2=O)OCO6)OCO5

IUPAC Name

(1S,12R,13S,14R,16R,23R)-13,14-dimethyl-2,6,8,20,22-pentaoxahexacyclo[10.10.1.01,19.03,11.05,9.016,23]tricosa-3,5(9),10,18-tetraen-17-one

InChIKey

GMTJIWUFFXGFHH-WPAOEJHSSA-N

INCHI

1S/C20H20O6/c1-9-3-11-13(21)5-17-20(25-8-24-17)19(11)18(10(9)2)12-4-15-16(23-7-22-15)6-14(12)26-20/h4-6,9-11,18-19H,3,7-8H2,1-2H3/t9-,10+,11+,18+,19+,20+/m1/s1

Isómeros SMILES

C[C@@H]1C[C@@H]2[C@H]3[C@@H]([C@H]1C)C4=CC5=C(C=C4O[C@@]36C(=CC2=O)OCO6)OCO5

PubChem CID

11725801

Peso molecular

356.37

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzopyrans
      • Subclass 1-benzopyrans
        • Level5 Dibenzopyrans
          • Level6 Xanthenes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans
• Direct Parent: Xanthenes
• Alternative Parents: Benzodioxoles Ketals Cyclohexenones Benzenoids Vinylogous esters 1,3-dioxolanes Oxacyclic compounds Organic oxides Hydrocarbon derivatives Aldehydes
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthene - Benzodioxole - Cyclohexenone - Ketal - Benzenoid - Vinylogous ester - Meta-dioxolane - Ketone - Oxacycle - Acetal - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Carbonyl group - Aldehyde - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO, and chloroform.
• Sensibilidad: light sensitive
• Índice de refracción: n20D1.64 (Predicted)
• Punto de ebullición (°C): 498.10° C at 760 mmHg (Predicted)
• Punto de fusión (°C): 186.28° C (Predicted)
• Peso molecular: 356.400 g/mol
• XLogP3: 2.800
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 356.126 Da
• Monoisotopic Mass: 356.126 Da
• Topological Polar Surface Area: 63.200 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 675.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 6
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.