SB 220025 - Moligand™, 10 mM in DMSO , CAS No.165806-53-1

CAS: 165806-53-1 Cat. No.: S1494614 Fórmula: C₁₈H₁₉FN₆ Peso molecular: 338.38 Número EC: 827-712-1 PubChem CID: 5164

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor ( IC 50 = 60 nM). SB 220025 also inhibits p56 Lck and PKC with IC 50 values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

Specifications

Especificaciones y pureza

Moligand™, 10 mM in DMSO

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Propiedades del producto

• pKa: pKₐ: 9.92 (Predicted)
• Datos Ki: Casein kinase I δ: Ki= 12.59 nM (human); Casein kinase I α: Ki= 12.59 nM (human); Tyrosine-protein kinase LCK: Ki= 125.89 nM (human); PKC ν: Ki= 251.19 nM (human); Lyn: Ki= 316.23 nM (human)

Nombres e identificadores

• Isómeros SMILES: C1CNCCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F
• PubChem CID: 5164
• Peso molecular: 338.38

Propiedades químicas y físicas

• Índice de refracción: n20D1.71 (Predicted)
• Punto de ebullición (°C): 611.86° C at 760 mmHg (Predicted)
• Punto de fusión (°C): 242.54° C (Predicted)

Preguntas frecuentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 165806-53-1, the molecular formula is C18H19FN6, and the molecular weight is 338.38 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.