SB 258719 - 10mM in DMSO , CAS No.195199-95-2

CAS: 195199-95-2 Cat. No.: S656823 Fórmula: C₁₈H₃₀N₂O₂S Peso molecular: 338.51 Número EC: 110-928-9 PubChem CID: 5312148

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

SB 258719 is a selective 5-HT 7 receptor antagonist with high affinity ( pK i =7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease

In Vitro

SB 258719 (1, 3 and 10 μM; HEK 293 cells) produces a concentration-related rightward-shift of the 5-CT concentration-response curve with no signifcant alteration in the maximal response to 5-CT. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Swiss Webster mice (20-25 g). Dosage: 5-20 mg/kg Administration: I.p. Result: Significantly attenuated the 5-CT-induced hypothermia.

IC50& Target:5-HT 7 Receptor 7.5 (pKi)

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

SB 258719 is a selective 5-HT 7 receptor antagonist with high affinity ( pK i =7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: CC1CCN(CC1)CC[C@@H](C)N(C)S(=O)(=O)C2=CC=CC(=C2)C
• PubChem CID: 5312148
• Peso molecular: 338.51

Objetivos asociados (humanos)

HTR7 Tclin 5-hydroxytryptamine receptor 7 (0 Activities)

Discover Target: HTR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)