SB225002 - Moligand™, 10mM in DMSO , Antagonist of CXCR2, CAS No.182498-32-4, Antagonist of CXCR2

CAS: 182498-32-4 Cat. No.: S409104 Fórmula: C₁₃H₁₀BrN₃O₄ Peso molecular: 352.14 Número EC: 803-197-9 PubChem CID: 3854666

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

SB225002 SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.
In vitro

In vitro, SB225002 inhibits GROα-stimulated calcium mobilization, and potently inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha. SB 225002 substantially reduces the levels of phosphorylated ERK1/2, and decreases cell proliferation in WHCO1 cells. SB225002 also shows the antitumor activity as a microtubule inhibitor.

In vivo

In rabbits, SB225002 selectively blocks IL-8-induced neutrophil margination. In mouse intrahepatic cholangiocellular carcinoma model, SB225002 (1 mg/kg i.p.) suppresses the growth of transplanted subcutaneous tumors. In addition, SB225002 also displays long-lasting antinociceptive effects, and reduces TNBS-induced colitis in mouse models.
Cell Data

cell lines：

Concentrations：400 nM

Incubation Time：6 days

Powder Purity:≥99%

Specifications

Sinónimos

N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ANTAGONIST

Mecanismo de acción

Antagonist of CXCR2

Nombres e identificadores

• Isómeros SMILES: C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
• PubChem CID: 3854666
• Peso molecular: 352.14

Objetivos asociados (humanos)

CXCR2 Tchem C-X-C chemokine receptor type 2 (5 Activities)

Discover Target: CXCR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CXCR1 Tchem C-X-C chemokine receptor type 1 (1 Activities)

Discover Target: CXCR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)