SC79 - 10mM in DMSO , CAS No.305834-79-1

CAS: 305834-79-1 Cat. No.: S408491 Fórmula: C₁₇H₁₇ClN₂O₅ Peso molecular: 364.8 Número EC: 974-068-3 PubChem CID: 2810830

GRADE & PURITY 10mM in DMSO

Synonyms

ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

SC79 SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.
In vitro

SC79 suppresses PH_AKTM-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells.

In vivo

In the permanent focal cerebral ischemia mouse model, SC79 (0.04 mg/g, i.p.) enables the cytosolic activation of Akt, and recapitulates the primary cellular function of Akt signaling, resulting in augmented neuronal survival.
Cell Data

cell lines：

Concentrations：8 μg/mL

Incubation Time：24 h

Powder Purity:

Specifications

Sinónimos

ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Nombres e identificadores

• Isómeros SMILES: CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Cl)N
• PubChem CID: 2810830
• Peso molecular: 364.8

Referencias

1. Tian-Shuang Xia, Sheng-Yan Xu, Li-Yong Lai, Yi-Ping Jiang, Na-Ni Wang, Hai-Liang Xin.  (2024)  Bitter acids from Humulus lupulus L. alleviate D-galactose induced osteoblastic senescence and bone loss via regulating AKT/mTOR-mediated autophagy.  JOURNAL OF FOOD AND DRUG ANALYSIS,  32  (4): (506).  [PMID:39752859] [10.38212/2224-6614.3508]

2. Zhuang Cuicui, Zhang Ruoqing, Bai Jiangang, Zhang Xinying, Zhao Jinhui.  (2024)  Lycopene promoted M2 macrophage polarization via inhibition of NOTCH1-PI3K-mTOR-NF-κB-JMJD3-IRF4 pathway in response to Escherichia coli infection in J744A.1 cells.  ARCHIVES OF MICROBIOLOGY,  206  (6): (1-11).  [PMID:38713385] [10.1007/s00203-024-03971-z]