≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Seconeolitsine, an antibiotic , and is an inhibitor of targeting topoisomerase I (TopA) . Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC 50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics
In Vitro
Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC 50 value of 17 μM and the inhibition of TopA is enhanced by preincubation of the enzyme with the alkaloid. Seconeolitsine shows great inhibition of S.pneumoniae growth with MIC 50 values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition of S. pneumoniae growth with MIC 50 values of 8 μM for CipR42, CipR68 and CipR15. Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1. Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner. Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Topoisomerase I 17 μM (IC 50 )
Specifications
Especificaciones y pureza
≥95%
Mecanismos bioquímicos y fisiológicos
Seconeolitsine, an antibiotic , and is an inhibitor of targeting topoisomerase I (TopA) . Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC 50 value of 17
Condiciones de almacenamiento de almacenamiento
Store at 2-8°C
Enviado en
Wet ice
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Pureza
≥95%
Nombres e identificadores
Sonrisas canónicas
CNCCC1=C2C=CC3=CC(OCO4)=C4C=C3C2=C5OCOC5=C1
Peso molecular
323.34
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
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Reseñas
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Preguntas frecuentes
What is the purity of this product?
This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.
How should this product be stored?
Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 2650074-56-7, the molecular formula is C19H17NO4, and the molecular weight is 323.34 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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