Sinomenine - Moligand™, 10mM in DMSO , CAS No.115-53-7

CAS: 115-53-7 Cat. No.: S408738 Molecular Weight: 329.39 EC Number: 204-094-6 PubChem CID: 5459308

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Cucoline, Kukoline | Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9α,13α,14α)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
In vitro

Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis. However its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Cucoline, Kukoline | Morphinan-6-one, 7, 8-didehydro-4-hydroxy-3, 7-dimethoxy-17-methyl-, (9α, 13α, 14α)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Sinomenine (Cucoline, Kukoline), a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: CN1CC[C@@]23CC(=O)C(=C[C@@H]2[C@@H]1CC4=C3C(=C(C=C4)OC)O)OC
• PubChem CID: 5459308
• Molecular Weight: 329.39

Chemical and Physical Properties

• Melt Point(°C): 180 °C (dec.)(lit.)

References

1. Zhou Zhiyong, Qiu Nanqing, Ou Yuntao, Wei Qianqian, Tang Wenting, Zheng Mingcong, Xing Yaluan, Li Jie-Jia, Ling Yong, Li Junxu, Zhu Qing.  (2021)  N-Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and inflammatory pain in mice.  Scientific Reports,  11  (1): (1-9).  [PMID:33927244] [10.1038/s41598-021-88521-z]

2. Yuntao Ou, Man Su, Yong Ling, Qianqian Wei, Fei Pan, Jiejia Li, Jun-Xu Li, Qing Zhu.  (2018)  Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:29408089] [10.1016/j.ejphar.2018.01.044]

3. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu.  (2016)  Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:27031576] [10.1016/j.jpba.2016.03.033]

4. Qing Zhu, Yuehua Sun, Lina Mao, Chengpeng Liu, Bo Jiang, Wei Zhang, Jun-Xu Li.  (2016)  Antinociceptive effects of sinomenine in a rat model of postoperative pain.  BRITISH JOURNAL OF PHARMACOLOGY,  173  (10): (1693-1702).  [PMID:26915970] [10.1111/bph.13470]

5. Qing Wang, Yao Long, Lin Yao, Li Xu, Zhi-Guo Shi, Lanying Xu.  (2015)  Preparation, characterization and application of a reversed phase liquid chromatography/hydrophilic interaction chromatography mixed-mode C18-DTT stationary phase.  TALANTA,      [PMID:26695288] [10.1016/j.talanta.2015.09.009]

6. Qing Wang, Zhi-Yuan Luo, Mao Ye, Yu-Zhuo Wang, Li Xu, Zhi-guo Shi, Lanying Xu.  (2015)  Preparation, chromatographic evaluation and application of adenosine 5′-monophosphate modified ZrO2/SiO2 stationary phase in hydrophilic interaction chromatography.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:25627970] [10.1016/j.chroma.2015.01.017]

7. Ji Chen, Peng Guo, Xinxin Liu, Huizhi Liao, Kemin Chen, Yuxia Wang, Jie Qin, Fengrui Yang.  (2023)  Sinomenine alleviates diabetic peripheral neuropathic pain through inhibition of the inositol-requiring enzyme 1 alpha–X-box binding protein 1 pathway by downregulating prostaglandin-endoperoxide synthase 2.  Journal of Diabetes Investigation,  14  (3): (364-375).  [PMID:36692011] [10.1111/jdi.13938]

8. Zhu Qing, Sun Yuehua, Zhu Jie, Fang Tian, Zhang Wei, Li Jun-Xu.  (2014)  Antinociceptive effects of sinomenine in a rat model of neuropathic pain.  Scientific Reports,  4  (1): (1-5).  [PMID:25434829] [10.1038/srep07270]