SPL-707 - ≥99% , CAS No.2195361-33-0

CAS: 2195361-33-0 Cat. No.: S648080 Fórmula: C₂₇H₂₈FN₅O₄ Peso molecular: 505.54

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC 50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase ( IC 50 =6.1 μM) and SPP ( IC 50 =3.7 μM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells

In Vitro

SPL-707 (Compound 40) inhibits mouse SPPL2a (IC 50 =0.18 μM), rat SPPL2a (IC 50 =0.056 μM) and human SPPL2a (IC 50 =0.16 μM), human SPPL2b (IC 50 =0.43 μM) by a high content imaging assay (HCA). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SPL-707 (Compound 40; 3-30 mg/kg; orally; b.i.d.; for 11 days) leads to a reduction in B cells and myeloid dendritic cells without affecting γ-secretase activity . SPL-707 (3 mg/kg of po and 1 mg/kg of iv) has a CL of 6 mL/min•kg, and an AUC of 8787 h•nM . SPL-707 (1, 3 mg/kg; b.i.d.; first dose at 0 h, second dose at 8 h) achieves full inhibition of CD74/p8 processing in spleen in female Lewis rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice with 5-12 weeks of age Dosage: 3, 10, and 30 mg/kg Administration: Orally; b.i.d. (with 8 and 16 h dosing intervals); for 11 days Result: Led to a reduction in B cells and myeloid dendritic cells without affecting γ-secretase activity. Animal Model: Female Sprague−Dawley rat Dosage: 3 mg/kg of po and 1 mg/kg of iv (Pharmacokinetic Analysis) Administration: PO or IV Result: Had a CL of 6 mL/min•kg, and an AUC of 8787 h•nM.

Form:Solid

IC50& Target:IC50: 77 nM (SPPL2a), 6.1 μM (γ-secretase) and 3.7 μM (SPP)

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC 50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase ( IC 50 =6.1 μM) and SPP ( IC 50 =3.7 μM). SPL-707 has the potential for autoimmune diseases resear

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CC1=C(NC(C[C@@H](C2CC2)C(N[C@@H]3C(N(CC4(CC4)C5)N5C(C6=C3C=CC=C6)=O)=O)=O)=O)C=C(F)C=N1
• Peso molecular: 505.54

Propiedades químicas y físicas

• Solubilidad: DMSO : 100 mg/mL (197.81 mM; Need ultrasonic)

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2195361-33-0, the molecular formula is C27H28FN5O4, and the molecular weight is 505.54 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.