STAT3-IN-3 - ≥98% , CAS No.2361304-26-7

CAS: 2361304-26-7 Cat. No.: S649834 Fórmula: C₂₇H₂₆BrN₃O₆S Peso molecular: 600.48

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3) , with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research

In Vitro

STAT3-IN-3 has no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2. STAT3-IN-3 inhibits the growth of MDA-MB-231, HCT-116, HepG2, and MCF-7 cells with IC 50 s of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM, respectively. STAT3-IN-3 down-regulates the expression of STAT3 target genes Bcl-2 and Cyclin D1. STAT3-IN-3 inhibits STAT3 tyrosine phosphorylation and serine phosphorylation. STAT3-IN-3 inhibits STAT3 DNA-binding activity. STAT3-IN-3 (1-4 μM; 24 hours) increases ROS production and remarkably reduces the mitochondrial membrane potential to induce mitochondrial apoptotic pathway. STAT3-IN-3 (1-4 μM; 24 hours) can induce the cleavage of caspase-9, caspase-3 and PARP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MDA-MB-231 cells, HCT-116 cells, HepG2 cells, MCF-7cells Concentration: MTT assay Incubation Time: 48 hours Result: Exhibited anti-proliferative activity. Apoptosis AnalysisCell Line: MDA-MB-231 cells Concentration: 0 μM, 1 μM, 2 μM, 4 μM Incubation Time: 24 hours Result: Induced the apoptosis of MDA-MB-231 cells dose-dependently and the apoptosis rates. Western Blot AnalysisCell Line: MDA-MB-231 cells Concentration: 0 μM, 1 μM, 2 μM, 4 μM Incubation Time: 24 hours Result: Induced the cleavage of caspase-9, caspase-3 and PARP.

In Vivo

STAT3-IN-3 (10mg/kg-20 mg/kg; i.p.; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult female BALB/c mice (6 weeks of age) Dosage: 10 mg/kg, 20 mg/kg Administration: Intraperitoneal injection, daily, for 14 days Result: Significantly inhibited tumor volume.

Form:Solid

IC50& Target:STAT3

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3) , with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STA

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: BrC1=C2C(S(C(C(N3CCN(C(C4=CC5=CC=C(N(CC)CC)C=C5OC4=O)=O)CC3)=O)=C2)(=O)=O)=CC=C1
• Peso molecular: 600.48

Propiedades químicas y físicas

• Solubilidad: DMSO : 5 mg/mL (8.33 mM; Need ultrasonic)

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2361304-26-7, the molecular formula is C27H26BrN3O6S, and the molecular weight is 600.48 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.