Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Argon charged,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Tacrine is an effective oral acetylcholine ( AChE ) inhibitor ( IC 50 = 109 nM) and also acts as an active substrate for CYP1A2 . Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease .
| Isómeros SMILES | C1CCC2=NC3=CC=CC=C3C(=C2C1)N |
|---|---|
| PubChem CID | 1935 |
| Peso molecular | 198.26 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Punto de fusión (°C) | 183℃ |
|---|
| 1. Zhifei Wang, Lianghui Ma, Xiaodan Qi, Lihua Jin, Yehua Shen. (2025) Preparation of carbon dots modified activated carbon nanostructures and their application in colorimetric detection of acetylcholinesterase activity. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.114796] |
| 2. Hong Yao, Giuseppe Uras, Pengfei Zhang, Shengtao Xu, Ying Yin, Jie Liu, Shuai Qin, Xinuo Li, Stephanie Allen, Renren Bai, Qi Gong, Haiyan Zhang, Zheying Zhu, Jinyi Xu. (2021) Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:34024109] [10.1021/acs.jmedchem.1c00160] |
| 3. Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li. (2023) Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, [PMID:38052155] [10.1016/j.ejmech.2023.116013] |
| 4. Yang Mao-Hui, Zhou Xin, Yang Yan, Chen Hua-Guo. (2023) Effects of different extraction methods on the structural characterization and bioactivities of polysaccharides extracted from Polygonatum sibiricum. Journal of Food Measurement and Characterization, [PMID:] [10.1007/s11694-023-02238-3] |
| 5. Chen Tingting, Qin Yingfeng, Wang Beibei, Lai Rongji, Tan Guohe, Liu Jin-Wen. (2023) Enzymatic reaction modulated DNA assembly on graphitic carbon nitride nanosheets for sensitive fluorescence detection of acetylcholinesterase activity and inhibition. MICROCHIMICA ACTA, 190 (7): (1-10). [PMID:37338607] [10.1007/s00604-023-05850-8] |
| 6. Yingying Chen, Wenxia Liu, Binbin Zhang, Zhiguang Suo, Feifei Xing, Lingyan Feng. (2020) Sensitive and reversible perylene derivative-based fluorescent probe for acetylcholinesterase activity monitoring and its inhibitor. ANALYTICAL BIOCHEMISTRY, [PMID:32739347] [10.1016/j.ab.2020.113835] |
| 7. Yeheng Zhou, Wei Sun, Jiale Peng, Hui Yan, Li Zhang, Xingyong Liu, Zhili Zuo. (2019) Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments. BIOORGANIC CHEMISTRY, [PMID:31585263] [10.1016/j.bioorg.2019.103322] |
| 8. Jing Xu, Fengqi Zhou, Luxi Chen, Guilin Chen, Saifei Pan, Zhaosheng Qian, Hui Feng. (2017) Thiol-triggered disaggregation-induced emission controlled by competitive coordination for acetylcholinesterase monitoring and inhibitor screening. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2017.08.044] |
| 9. Na Wang, Yi Liu, Can Yang, Jiana Du, Dehong Yu, Pei He, Haiqi Xu, Lizi Li, Puchen Zhao, Yanfang Li. (2024) Molecular insights into vasicine and butyrylcholinesterase interactions: A complimentary biophysical, multi-spectroscopic, and computational study. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39733876] [10.1016/j.ijbiomac.2024.139253] |
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