TC11 - ≥98% , CAS No.100823-03-8

CAS: 100823-03-8 Cat. No.: T413516 Fórmula: C₂₀H₂₂N₂O₂ Peso molecular: 322.40 PubChem CID: 1235479

GRADE & PURITY ≥98%

Synonyms

TC11 | CS-0105753 | 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione | HY-129478 | SCHEMBL2818285 | 5-Amino-2-(2,6-diisopropyl-phenyl)-isoindole-1,3-dione | AKOS040759656 | BS-47334 | 2-(2,6-diisopropylphenyl)-5-amino-1h-isoindole-1,3-dione | 1H-I

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Information

TC11 (CLT-003) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.

Specifications

Sinónimos

TC11 | CS-0105753 | 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione | HY-129478 | SCHEMBL2818285 | 5-Amino-2-(2,6-diisopropyl-phenyl)-isoindole-1,3-dione | AKOS040759656 | BS-47334 | 2-(2,6-diisopropylphenyl)-5-amino-1h-isoindole-1,3-dione | 1H-I

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

TC11 (CLT-003) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disrupt

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 528767369
• Sonrisas canónicas: CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N
• IUPAC Name: 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione
• InChIKey: NRPIRIUWEKTNGQ-UHFFFAOYSA-N
• INCHI: 1S/C20H22N2O2/c1-11(2)14-6-5-7-15(12(3)4)18(14)22-19(23)16-9-8-13(21)10-17(16)20(22)24/h5-12H,21H2,1-4H3
• Isómeros SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N
• PubChem CID: 1235479
• Peso molecular: 322.40

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Isoindoles and derivatives
      • Subclass Isoindolines
        • Level5 Isoindolones
          • Level6 Phthalimides

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Isoindoles and derivatives
• Subclass: Isoindolines
• Intermediate Tree Nodes: Isoindolones
• Direct Parent: Phthalimides
• Alternative Parents: Phenylpropanes Isoindoles Cumenes N-substituted carboxylic acid imides Amino acids and derivatives Azacyclic compounds Primary amines Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phthalimide - Cumene - Isoindole - Phenylpropane - Monocyclic benzene moiety - Benzenoid - Carboxylic acid imide, n-substituted - Carboxylic acid imide - Amino acid or derivatives - Carboxylic acid derivative - Azacycle - Amine - Organonitrogen compound - Organooxygen compound - Primary amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phthalimides. These are aromatic heterocyclic compounds containing a 1,3-dioxoisoindoline moiety. They are imide derivatives of phthalic anhydrides.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

ANPEP Tchem Aminopeptidase N (863 Activities)

Discover Target: ANPEP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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PC-3 (62116 Activities)

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WI-38 (2654 Activities)

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HUVEC (11049 Activities)

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MDA-MB-231 (73002 Activities)

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Objetivos asociados (no humanos)

DPP4 Dipeptidyl peptidase IV (11 Activities)

Discover Target: DPP4

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Sus scrofa (849 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Light sensitive
• Peso molecular: 322.400 g/mol
• XLogP3: 4.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 322.168 Da
• Monoisotopic Mass: 322.168 Da
• Topological Polar Surface Area: 63.400 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 486.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1